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| http://dx.doi.org/10.3324/haematol.2016.144519 | DOI Listing |
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- * 60 thalassemia patients were divided into three groups based on their chelation treatments: oral deferiprone daily, subcutaneous deferoxamine four times weekly, and a combination of both therapies.
- * Results show that the combination therapy was the most effective in reducing iron levels and improving urinary iron excretion, while patients on deferoxamine had the least hepatic iron deposition, though still above normal levels.
Transfusional hemosiderosis in childhood cancer patients and survivors.
Pediatr Blood Cancer
October 2024
Children's Center for Cancer, Blood Diseases and Bone Marrow Transplantation, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Background: Children treated for cancer are at risk for adverse effects of iron due to transfusions administered during prolonged marrow suppression, which may increase exposure to toxic forms of iron, extrahepatic iron accumulation, and long-term organ damage.
Objective: This study aimed to characterize the severity and organ distribution of clinically significant, multisystem iron overload (IO) in an at-risk cohort of pediatric cancer patients.
Methods: This was a retrospective, cross-sectional study of childhood cancer patients who underwent a magnetic resonance imaging (MRI) due to clinical concern for IO.
Significant pituitary siderosis is common in transfusion-dependent sickle cell disease.
Blood
September 2024
Keck School of Medicine, University of Southern California, Los Angeles, CA.
Chronically transfused patients with sickle cell disease typically do not exhibit iron-mediated extrahepatic toxicity. However, we demonstrate that the pituitary gland is vulnerable to iron deposition, and it occurs regardless of other extrahepatic involvement. Severe pituitary siderosis is associated with early organ dysfunction.
View Article and Find Full Text PDFCase report: A rare case of hereditary hemochromatosis caused by a mutation in the HAMP gene in Fuyang, China.
Front Med (Lausanne)
June 2024
Department of Hepatology, The Second People's Hospital of Fuyang City, Fuyang, Anhui, China.
Article Synopsis
- * Symptoms can differ among individuals, making diagnosis challenging, and some may show no signs at all.
- * This case report highlights a rare instance of hereditary hemochromatosis linked to a mutation in the HAMP gene in Fuyang City, China, to improve clinicians' understanding and reduce misdiagnosis.
Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients.
Scand J Clin Lab Invest
July 2024
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: Major Thalassemia patients suffer from iron overload and organ damage, especially heart and liver damage. Early diagnosis and treatment with a chelator can reduce the complications and mortality of iron overload. Therefore, we aimed to investigate the biochemical and hematological predictors as an alternative and indirect indicator of iron deposition in heart and liver cells in comparison with the MRI T2* method as the gold standard.
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