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Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women. | LitMetric

AI Article Synopsis

  • Anti-C1q antibodies are associated with autoimmune thyroid disorders in pregnant women and were found to be higher in those with thyroid dysfunction compared to healthy controls.
  • In a study with 96 pregnant women positive for AITD, anti-C1q levels increased during pregnancy, particularly in those with thyroid antibodies, and correlated with higher thyroid-stimulating hormone (TSH) levels.
  • After delivery, anti-C1q levels decreased in TPOAb-negative women but remained elevated in TPOAb-positive women, with no further correlation to TSH.

Article Abstract

Anti-C1q antibodies (anti-C1q) have been implicated in the pathogenesis of autoimmune diseases, including autoimmune thyroid disorders (AITD). The aim of this study was to evaluate the association between anti-C1q and thyroid function in pregnancy-associated AITD. In 96 pregnant women screened positive for AITD (thyroid dysfunction and/or antibodies against thyroperoxidase - TPOAb), anti-C1q were measured during the 9-11th gestational week and after delivery (median 16 months after delivery), and compared to the corresponding serum levels of thyroid hormones. As controls, 80 healthy pregnant women, 72 non-pregnant AITD patients and 72 blood donors were included. In the non-pregnant AITD group, two serum samples ≥ 6 months apart were analysed. Compared to blood donors, anti-C1q levels were substantially higher in all pregnant women analysed. In pregnancy, anti-C1q levels were higher in the TPOAb-positive women than in controls (37 versus 17·5%, P < 0·0001). Anti-C1q-positive pregnant women screened positive for AITD had higher thyroid-stimulating hormone (TSH) levels than anti-C1q-negative women (2·41 versus 1·94 mU/l, P = 0·01), and TSH correlated positively with anti-C1q (r = 0·226, P = 0·045) in the TPOAb-positive women. After delivery, serum levels of anti-C1q decreased in the positively screened TPOAb-negative women (8·8 versus 5·9 U/l, P = 0·002), but not in the TPOAb-positive ones, and they no longer correlated with TSH. Anti-C1q antibody levels increase during pregnancy in general and even more in the context of AITD, where they correlate with thyroid stimulating hormone levels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011361PMC
http://dx.doi.org/10.1111/cei.12813DOI Listing

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