AI Article Synopsis
- - The study compared the effects of simvastatin (SMV) and simvastatin nanoliposome (SMV-Lipo) on heart remodeling in male mice using two different administration methods: intragastric (i.g.) and intraperitoneal (i.p.).
- - Results showed that SMV-Lipo given through the i.p. route was more effective in reducing cardiac issues like hypertrophy and inflammation compared to crude SMV and the i.g. method.
- - Additionally, the pharmacokinetic analysis indicated that both i.p. and i.g. routes significantly increased plasma levels of SMV when using SMV-Lipo, highlighting its superior absorption and effectiveness in combating cardiac remodeling.
Article Abstract
In this study, simvastatin (SMV) and SMV nanoliposome (SMV-Lipo) were given to male BALB/c mice by either intragastric (i.g.) or intraperitoneal (i.p.) administration, and their effects on isoproterenol (ISO)-induced cardiac remodeling were compared. The results indicate that by i.p. administration, the SMV-Lipo at an equal SMV dose exhibited more significant inhibitory effects than the crude SMV on cardiac hypertrophy, fibrosis and inflammation. Comparing the SMV-Lipo on different administration regimens, i.p. group showed more significant inhibitory effects on cardiac remodeling than i.g. group. In addition, pharmacokinetic studies revealed that SMV-Lipo administrated by either i.p. or i.g. more significantly improved the plasma SMV concentration than the crude SMV. Therefore, the SMV-Lipo significantly enhanced the inhibitory effects of SMV on cardiac remodeling resulted from the enhanced absorption of SMV by nanoliposome formulation, and i.p. was better than i.g. administration.
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| http://dx.doi.org/10.1016/j.nano.2016.05.002 | DOI Listing |
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