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ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. | LitMetric

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis.

G3 (Bethesda)

Department of Computer Science, University of California, Los Angeles, California 90095 Department of Human Genetics, University of California, Los Angeles, California 90095

Published: July 2016

AI Article Synopsis

Article Abstract

Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies. Heterogeneity complicates the interpretation of meta-analyses. In this paper, we describe ForestPMPlot, a flexible visualization tool for analyzing studies included in a meta-analysis. The main feature of the tool is visualizing the differences in the effect sizes of the studies to understand why the studies exhibit heterogeneity for a particular phenotype and locus pair under different conditions. We show the application of this tool to interpret a meta-analysis of 17 mouse studies, and to interpret a multi-tissue eQTL study.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938634PMC
http://dx.doi.org/10.1534/g3.116.029439DOI Listing

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