AI Article Synopsis
- The approval of the first 3D-printed drug by the FDA has sparked significant interest in the application of 3D printing in healthcare, indicating its potential to transform the industry.
- The paper reviews various 3D printing techniques used in pharmaceuticals, focusing on their ability to create complex oral dosage forms and tailored release profiles.
- It also addresses the technical and regulatory challenges that need to be tackled for 3D printing to be fully integrated into pharmaceutical manufacturing.
Article Abstract
The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.
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| http://dx.doi.org/10.1007/s11095-016-1933-1 | DOI Listing |
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