Visceral leishmaniasis (VL) is a ftial and growing public health problem in Ethiopia. VL is recently reported outside the major endemic foci, the lowlands in the northwest and the Omo and Abaroba-plain, Segen and Woito valleys in the southwest. Here, we report a visceral leishmaniasis case from Benishangul-Gumuz Regional state near the Guba area. The patient had no history of travel to known VL endemic areas. The patient is a temporary farm laborer from West Go'jam Zone, Wanbermna District in Amhara Regional State. While in Benishangul-Gumuz, the patient was diagnosed with prolonged and intermittentfever, epistaxis, splenomegaly, skin pallor, diarrhea, cough and oedema. Laboratory diagnosis results showed that he had marked leucopenia, thrombocytopenia and anemia. The patient was suspected of having VL and checked with rK39 immunochromnatography and direct agglutination tests which were positive for anti leishmanial antibodies. After getting full dose of sodium stibogluconate as per the national visceral leishmaniasis treatment guideline, was clinically cured. As the area in Benshangul-Gumuz where this patient contracted visceral leishmaniasis is under social and ecological transformation with large scale projects attracting huge influx of temporary laborers and settlers, due attention is needed with respect to introduction or emergence of VL transmission.

Download full-text PDF

Source

Publication Analysis

Top Keywords

visceral leishmaniasis
20
regional state
12
report visceral
8
visceral
5
patient
5
leishmaniasis area
4
area endemic
4
endemic dangur
4
dangur benshangul-gumuz
4
benshangul-gumuz regional
4

Similar Publications

Although Switzerland is currently not endemic for canine leishmaniosis (CanL), imported cases of this emerging zoonosis are regularly detected. Also, phlebotomine sand flies, vectors of the causative agent , are present in the southern part of the country, in Canton Ticino, and endemic foci of CanL have been recently described in neighboring Italian municipalities. In 2022 and 2023, we evaluated the distribution of phlebotomine sand flies and the presence of antibodies against in domestic dogs and cats in Ticino and Mesolcina (Canton of Grisons).

View Article and Find Full Text PDF

, considered a potential vector for visceral leishmaniasis (VL), is distributed in the southern Gansu and northern Sichuan regions in China. However, the high similarity in the morphology of and s.s.

View Article and Find Full Text PDF

Leishmania sp. can affect the cardiovascular system of dogs - A systematic review of over 80 years.

Vet Parasitol

January 2025

Department of Veterinary Clinic and Surgery, Veterinary School, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, Brazil; National Institute of Science and Technology in NanoBiopharmaceutics (INCT-Nanobiofar), Belo Horizonte, Minas Gerais, Brazil.

Cardiovascular involvement in Leishmania sp. infections still requires further elucidation, with cutaneous and organic changes being more frequently observed. The aim of this study was to conduct a systematic review of cardiovascular involvement in dogs with canine visceral leishmaniasis, considering a publication span of over 80 years.

View Article and Find Full Text PDF

Leishmaniases affect millions of people around the world, caused by Leishmania parasites. Leishmania are transmitted by female sandflies from Phlebotominae subfamily during their blood meals. In mammals, promastigotes are phagocytosed mainly by macrophages, differentiate into amastigotes and multiply.

View Article and Find Full Text PDF

Deep Multitask Learning-Driven Discovery of New Compounds Targeting .

ACS Omega

December 2024

Laboratory of Cheminformatics, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia 74605-170, Brazil.

Article Synopsis
  • Visceral leishmaniasis is a serious disease primarily found in low- and middle-income countries, with limited treatment options due to toxicity and drug resistance.
  • Researchers developed a multitask learning (MTL) pipeline to predict the effectiveness of compounds against several species, screening about 1.3 million compounds and finding 20 potential candidates with significant antileishmanial activity.
  • Three of these compounds showed strong efficacy and moderate safety, suggesting they could lead to new therapies, while the use of explainable models aids in understanding how these compounds work, potentially improving drug discovery for neglected tropical diseases.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!