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BBL enzymes exhibit enantiospecific preferences in the biosynthesis of pyridine alkaloids in Nicotiana tabacum L.
Phytochemistry
April 2025
Department of Crop and Soil Science, North Carolina State University, Raleigh, NC, USA. Electronic address:
Plant species can accumulate secondary metabolites in optically pure form or, occasionally, as enantiomeric mixtures. Interestingly, enantiomers of the same molecule can confer different biological activities. In tobacco (Nicotiana tabacum L.
View Article and Find Full Text PDFThe Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines.
Molecules
November 2024
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania.
6-hydroxy-L-nicotine (6HLN) is a nicotine (NIC) derivative with proven therapeutic potential in neurodegenerative disorders. Here, the impact of 6HLN on cell growth, migratory behavior, and inflammatory status of three different cancer cell lines (A549, MCF7, and U87) and two normal cell lines (16HBE14o and MCF10A) was investigated. In silico analyses were conducted to evaluate the binding affinity of 6HLN to nicotinic receptors (nAChRs) containing α9 and α5 subunits.
View Article and Find Full Text PDFExposure to nicotine and withdrawal in Wistar rats: an electrophysiological study.
Nicotine Tob Res
October 2024
Laboratory of the Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará.
Article Synopsis
- Smoking is a leading cause of preventable death globally, with nicotine affecting brain activity related to addiction and heart function, potentially leading to heart rhythm issues.
- A study was conducted on Wistar rats to examine EEG and ECG patterns during nicotine exposure, withdrawal, and relapse, focusing on the impact on brainwaves and heart conduction.
- Findings reveal that high-frequency brainwaves relate to nicotine dependence, while withdrawal emphasizes slower brain oscillations tied to cravings; nicotine can cause heart abnormalities that slightly improve with withdrawal but worsen during relapse.
Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents.
Exp Brain Res
December 2024
Neuromodulation Center, Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Fibromyalgia syndrome (FMS) is a complex, chronic condition often marked by widespread pain and fatigue, primarily affecting women, leading to challenges in diagnosis and treatment.
- This study investigated the link between transcranial magnetic stimulation (TMS) metrics—like cortical excitability and inhibition—and various clinical characteristics in 108 FMS patients, revealing associations between TMS markers, pain severity, fatigue, and medication use.
- Findings suggest that disrupted brain inhibitory functions are linked to FMS symptoms, with factors like gabapentinoids and nicotine potentially impacting the brain's pain modulation mechanisms.
E-Cigarettes induce expression of procoagulant tissue factor in cultivated human endothelial cells.
J Thromb Thrombolysis
August 2024
Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples "Federico II", Via Pansini, 5, Naples, 80131, Italy.
Background: E-cigarettes (ECIG) are proposed as an alternative for regular tobacco users with less dangerous effects for health. Several studies demonstrated that ECIG exert deleterious cardiovascular effects and promote platelet dependent thrombosis. However, ECIG role on Tissue Factor-dependent thrombosis is still unknown.
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