AI Article Synopsis
- The study aimed to compare the effects of ibuprofen and codeine on posttonsillectomy bleeding in pediatric patients.
- A total of 6014 tonsillectomy patients were analyzed, with 211 experiencing post-surgery hemorrhages, showing similar rates of bleeding for both ibuprofen (3.6%) and codeine (3.4%).
- The researchers concluded that while age is a risk factor for bleeding, there is no significant difference in posttonsillectomy bleeding between ibuprofen and codeine when age is considered.
Article Abstract
Objective: To determine the effect of ibuprofen on posttonsillectomy bleeding when compared with codeine in posttonsillectomy analgesia.
Study Design: Case series with chart review.
Setting: Tertiary care children's hospital, Philadelphia, Pennsylvania.
Subjects And Methods: On July 1, 2012, our institution transitioned from acetaminophen with codeine to ibuprofen for posttonsillectomy analgesia. Pediatric patients (0-18 years old) who underwent surgery from July 1, 2010, to June 30, 2012, were placed in the codeine cohort, and those who underwent surgery from July 1, 2012, to June 30, 2014, were placed in the ibuprofen cohort.
Results: A total of 6014 patients underwent tonsillectomy between July 1, 2010, and June 30, 2014, and 211 patients presented for posttonsillectomy hemorrhage during the same period. The incidence of readmission for posttonsillectomy hemorrhage was 3.4% and 3.6% (P = .63; odds ratio [OR] = 1.07; 95% confidence interval [95% CI]: 0.811-1.410) for the codeine and ibuprofen groups, respectively, and the incidence of second operation for control of posttonsillectomy bleeding for the codeine and ibuprofen groups was 1.9% and 2.2% (P = .54; OR = 1.117; 95% CI: 0.781-1.600), respectively. Patients aged 11 to 18 years demonstrated a higher incidence of posttonsillectomy bleeding events overall. When age is controlled, multivariate logistic regression demonstrated no statistically significant increase in posttonsillectomy bleeding events among pediatric patients treated with ibuprofen versus patients treated with codeine (readmission: P = .617; OR = 0.932; 95% CI: 0.707-1.228; reoperation: P = .513; OR = 0.887; 95% CI: 0.618-1.272).
Conclusion: Age is an independent risk factor for posttonsillectomy bleeding. When age is controlled, there is no statistically significant increase in the incidence of posttonsillectomy bleeding events among patients treated with ibuprofen when compared to patients treated with codeine.
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Source |
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| http://dx.doi.org/10.1177/0194599816646363 | DOI Listing |
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