AI Article Synopsis
- The text discusses a new method for using rhodium(III) as a catalyst to activate C-H bonds in heterocycles.
- This process allows for the construction of linear allyl structures that contain trifluoromethyl (CF3) groups.
- The reactions are selective, leading to the formation of products with trans configuration through a specific pathway that resembles an SN-type reaction.
Article Abstract
The rhodium(III)-catalyzed γ-trifluoromethylallylation of various heterocyclic C-H bonds with CF3-substituted allylic carbonates is described. These reactions provide direct access to linear CF3-containing allyl frameworks with complete trans-selectivity via C-H bond activation followed by a formal SN-type reaction pathway.
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| http://dx.doi.org/10.1021/acs.joc.6b00721 | DOI Listing |
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