We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC50 = 1.28 ± 0.03 μM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273488 | PMC |
| http://dx.doi.org/10.3390/molecules21050634 | DOI Listing |
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