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Effects of Brassicaceae Isothiocyanates on Prostate Cancer. | LitMetric

Effects of Brassicaceae Isothiocyanates on Prostate Cancer.

Molecules

Lennart Levi Stress and Neuroimmunology Laboratory, School of Medicine and Dentistry, University of Santiago de Compostela, c/San Francisco, s/n, 15782 Santiago de Compostela, A Coruña, Spain.

Published: May 2016

AI Article Synopsis

  • Cancer remains a leading cause of death, with prostate cancer (PCa) being one of the most common types among men, highlighting the need for more effective treatments.
  • Over 50% of current anticancer drugs are derived from natural sources, including isothiocyanates (ITCs), which have shown various therapeutic effects and potential in cancer prevention without significant toxicity.
  • ITCs can induce cell cycle arrest and apoptosis, enhance sensitivity of resistant PCa to other treatments, and affect epigenetic changes, leading to reduced cell growth and spread in cancer models.

Article Abstract

Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management of this disease requires developing better anticancer agents with greater efficacy and fewer side effects. Nature is a large source for the development of chemotherapeutic agents, with more than 50% of current anticancer drugs being of natural origin. Isothiocyanates (ITCs) are degradation products from glucosinolates that are present in members of the family Brassicaceae. Although they are known for a variety of therapeutic effects, including antioxidant, immunostimulatory, anti-inflammatory, antiviral and antibacterial properties, nowadays, cell line and animal studies have additionally indicated the chemopreventive action without causing toxic side effects of ITCs. In this way, they can induce cell cycle arrest, activate apoptosis pathways, increase the sensitivity of resistant PCa to available chemodrugs, modulate epigenetic changes and downregulate activated signaling pathways, resulting in the inhibition of cell proliferation, progression and invasion-metastasis. The present review summarizes the chemopreventive role of ITCs with a particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo cancer animal models.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272898PMC
http://dx.doi.org/10.3390/molecules21050626DOI Listing

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