AI Article Synopsis
- This study focused on understanding the physical properties of β-cyclodextrin polymers, specifically polyβ-CD and polyMe-β-CD, which enhance drug release capabilities.
- The polymers were analyzed using powder X-ray diffraction and differential scanning calorimetry, revealing they are amorphous and have high glass transition temperatures.
- Through the addition of plasticizers like trehalose and mannitol, researchers could estimate the glass transition temperatures of the polymers, determining values of approximately 317°C for polyMe-β-CD and 418°C for polyβ-CD.
Article Abstract
The aim of this work was to determine the main physical characteristics of β-cyclodextrin polymers, well known for improving complexation capacities and providing enhanced and sustained release of a large panel of drugs. Two polymers were investigated: a polymer of β-cyclodextrin (polyβ-CD) and a polymer of partially methylated (DS=0.57) β-cyclodextrin (polyMe-β-CD). The physical characterizations were performed by powder X-ray diffraction and differential scanning calorimetry. The results indicate that these polymers are amorphous and that their glass transition is located above the thermal degradation point of the materials preventing their direct observation and thus their full characterization. We could however estimate the virtual glass transition temperatures by mixing the polymers with different plasticizers (trehalose and mannitol) which decreases Tg sufficiently to make the glass transition observable. Extrapolation to zero plasticizer concentration then yield the following Tg values: Tg (polyMe-β-CD)=317°C±5°C and Tg (polyβ-CD)=418°C±6°C.
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| http://dx.doi.org/10.1016/j.carbpol.2016.04.032 | DOI Listing |
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