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Buried esophageal adenocarcinoma after radiofrequency ablation with pagetoid spreading.
Gastrointest Endosc
April 2024
Anatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Location and appearance of dysplastic Barrett's esophagus recurrence after endoscopic eradication therapy: no additional yield from random biopsy sampling neosquamous mucosa.
Gastrointest Endosc
November 2023
Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia.
Background And Aims: Surveillance after complete remission of intestinal metaplasia (CRIM) is essential. Current recommendations are to sample visible lesions first, followed by random 4-quadrant biopsy sampling of the original Barrett's esophagus (BE) length. To inform post-CRIM surveillance protocols, we aimed to identify the anatomic location, appearance, and histology of BE recurrences.
View Article and Find Full Text PDFA human Barrett's esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts.
Am J Physiol Gastrointest Liver Physiol
June 2022
Division of Gastroenterology, Department of Medicine, Baylor University Medical Center, Dallas, Texas.
Article Synopsis
- The study investigates the unknown causes of subsquamous intestinal metaplasia (SSIM) in Barrett's esophagus (BE) using a rat model, where glands are found beneath esophageal squamous tissue due to a wound-healing response.
- Researchers created human Barrett's organoids from patient biopsies and discovered that acidic bile salts can induce changes resembling EMP (epithelial-mesenchymal plasticity), which helps cells migrate and contributes to the development of SSIM.
- The findings suggest that reflux can trigger EMP in human Barrett's cells, allowing them to move beneath squamous tissue, potentially leading to SSIM, and the established organoids can serve as valuable models
Paleopathology of the Ychsma: Evidence of respiratory disease during the Late Intermediate Period (AD 1000-1476) at the Central Coastal site of Pachacamac, Peru.
Int J Paleopathol
September 2021
Faculté de Philosophie et Sciences Sociales CP133/01, Université libre de Bruxelles, Av. F. Roosevelt 50, 1050, Brussels, Belgium.
Objective: To investigate evidence for maxillary sinusitis and pulmonary inflammation in archaeological skeletons dating to the Late Intermediate Period (AD 1000-1476) at the site of Pachacamac, Peru.
Materials: Thirty-nine individuals (male, female, and unknown sex; 16+ years age-at-death) were analyzed for inflammatory periosteal reaction (IPR) on the visceral (inner) surfaces of the ribs, and 16 individuals were analyzed for evidence of maxillary sinusitis.
Methods: All individuals were macroscopically examined for bony changes in the maxillary sinuses and new bone formation on the ribs according to pre-established criteria.
Post-ablation buried neoplasia in Barrett's esophagus.
Scand J Gastroenterol
May 2021
Department of Gastroenterology, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Endoscopic eradication therapy (EET) with maximal acid suppression is the cornerstone for the management of patients with Barrett's esophagus (BE) associated dysplasia. The occurrence of buried dysplastic glands after re-epithelialization of a neo-squamous epithelium is of concern for endoscopists. Here, we present a patient with BE and high-grade dysplasia successfully treated by EET who developed buried dysplastic BE during surveillance.
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