A study was undertaken to investigate the kinematics of older users of passenger vehicles during ingress/egress and to seek correlations between their movement and comfort rating assigned by the subjects to the ease of vehicle ingress and egress. A principal component analysis was performed on the subjects' kinematics to identify the underlying modes of movement employed by the subjects. It was found that a small number of modes could describe the movements of all the subjects across all of the vehicles. Within the subspace defined by the modal vectors, shapes were found which correlated to the comfort rating for ease of ingress and egress which the subjects had assigned to each of the cars. Knowledge of these shapes which correspond to good and poor ingress and egress will be useful to the designers of interiors and exteriors of passenger vehicles for the older person. It is recommended that vehicle designs for the older person should attempt to avoid body positions which require excessive ankle articulation and lumbar flexion/extension during ingress and egress.
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http://dx.doi.org/10.1016/j.apergo.2016.03.017 | DOI Listing |
PLoS Pathog
January 2025
Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America.
Lenacapavir (LEN) is a highly potent, long-acting antiretroviral medication for treating people infected with muti-drug-resistant HIV-1 phenotypes. The inhibitor targets multifaceted functions of the viral capsid protein (CA) during HIV-1 replication. Previous studies have mainly focused on elucidating LEN's mode of action during viral ingress.
View Article and Find Full Text PDFNat Commun
January 2025
State Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, 300071, P.R. China.
Two or more catalysts conducting multistep reactions in the same reactor, concurrent tandem catalysis, could enable (bio)pharmaceutical and fine chemical manufacturing to become much more sustainable. Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
School of Artificial Intelligence, Optics and Electronics (iOPEN), Northwestern Polytechnical University, Xi'an 710072, China.
This study presents a novel reflective fiber Fabry-Perot (F-P) salinity sensor. The sensor employs a femtosecond laser to fabricate an open liquid cavity, facilitating the unobstructed ingress and egress of the liquid, thereby enabling the direct involvement of the liquid in light transmission. Variations in the refractive index of the liquid induce corresponding changes in the effective refractive index of the optical path, which subsequently influences the output spectrum.
View Article and Find Full Text PDFAerosp Med Hum Perform
November 2024
Introduction: As next-generation space exploration missions require increased autonomy from crews, real-time diagnostics of astronaut health and performance are essential for mission operations, especially for determining extravehicular activity readiness. An augmented reality (AR) system may be a viable tool allowing holographic visual cueing to replace physical objects used in traditional assessments.
Methods: In this study, 20 healthy adults were compared in an Ingress and Egress Task and Obstacle Weave Task with holographic and physical objects to determine the effect of AR on performance.
Anal Chem
December 2024
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Ultramicro pipettes with circular orifices have practically become common probes in exploring the microscopic world, yet the versatility of differently shaped pipettes is undermined in the pore family. Herein, ultramicro triangular pipettes with a pseudotriangular-shaped orifice were fabricated by laser-pulling triangular quartz capillaries and characterized by microscopic and electrochemical methods. Then, the differences in the electrochemical behaviors of triangular and circular pores were revealed through experiments and simulations.
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