[New data on the metabolism and physiologic mechanisms of aspartame action].

A comprehensive investigation of the physiological action of aspartame was conducted in 11 volunteers (healthy subjects, aged 18-37 years, with normal bw), and in experiments on 90 male Wistar rats, that were given aspartame in doses of 40 and 4000 mg/kg during 90 days, and in 3 dogs with gastric fistulas according to Basov. The study of microsomal and lysosomal activities in the liver, the turnover rate of liver proteins and blood plasma in rats revealed changes in the activity of liver cathepsins and in blood plasma albumin life time. The reaction of food thermogenesis after aspartame intake was recorded in experiments on dogs, that received sham feeding, and in the volunteers. As a whole, in the experiments including aspartame intake in a permissible daily dose for humans (40 mg/kg) no unfavourable action of the agent on the metabolic parameters studied was recorded.