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http://dx.doi.org/10.4049/jimmunol.1600345 | DOI Listing |
J Clin Immunol
February 2023
Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Background: X-linked inhibitor of apoptosis protein (XIAP) deficiency is a severe immunodeficiency with clinical features including hemophagocytic lymphohistiocytosis (HLH) and inflammatory bowel disease (IBD) due to defective NOD2 responses. Management includes immunomodulatory therapies and hematopoietic stem cell transplant (HSCT). However, this cohort is particularly susceptible to the chemotherapeutic regimens and acutely affected by graft-vs-host disease (GvHD), driving poor long-term survival in transplanted patients.
View Article and Find Full Text PDFNat Med
December 2021
S.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Transl Stroke Res
August 2022
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road 88th, Hangzhou, 310016, China.
Cytokine
September 2020
Department of Pediatric and Congenital Cardiology, University Hospital Heidelberg, Germany. Electronic address:
Introduction: Congenital heart surgery with cardiopulmonary bypass (CPB) initiates an immune response which frequently leads to organ dysfunction and a systemic inflammatory response. Complications associated with exacerbated immune responses may severely impact the postoperative recovery. The objective was to describe the characteristics of monocyte subpopulations and neutrophils at the level of pattern recognition receptors (PRR) and the cytokine response after CPB in infants.
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