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Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders.
Front Immunol
January 2023
Hematology Centre, Department of Immunology and Inflammation, Imperial College, London, United Kingdom.
Introduction: Endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF), identified by its ability to support differentiation of hematopoietic cells into several types of myeloid cells, is now known to support maturation and maintain the metabolic capacity of mononuclear phagocytes including monocytes, macrophages, and dendritic cells. These cells sense and attack potential pathogens, present antigens to adaptive immune cells, and recruit other immune cells. Recombinant human (rhu) GM-CSF (e.
View Article and Find Full Text PDFBenchmarking Non-Targeted Metabolomics Using Yeast-Derived Libraries.
Metabolites
March 2021
Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria.
Non-targeted analysis by high-resolution mass spectrometry (HRMS) is an essential discovery tool in metabolomics. To date, standardization and validation remain a challenge. Community-wide accepted cost-effective benchmark materials are lacking.
View Article and Find Full Text PDFEffects of partial replacement of soybean meal with other protein sources in diets of lactating cows.
Animal
July 2019
1Faculdade de Zootecnia e Engenharia de Alimentos,Universidade de São Paulo,13635900, Pirassununga, São Paulo,Brazil.
The protein nutrition of dairy cows is of great importance because of its direct influence on milk production, reproductive efficiency, and feeding cost. Eight first-lactation Holstein cows were randomly assigned to two contemporary 4 × 4 Latin squares in a 2 × 2 factorial design to evaluate the effects of replacing soybean meal with yeast-derived microbial protein (YMP) as a protein source (0% or 1.5% of dry matter (DM)) and its combination with slow-release urea (SRU; 0% or 0.
View Article and Find Full Text PDFLactation performance of dairy cows fed yeast-derived microbial protein in low- and high-forage diets.
J Dairy Sci
April 2016
Alltech Inc., Brookings, SD 57006.
The objective of this study was to investigate the effect of substituting soybean meal products with yeast-derived microbial protein (YMP) on lactation performance in diets containing 2 forage-to-concentrate ratios. Sixteen Holstein cows (4 primiparous and 12 multiparous) were randomly assigned to multiple 4 × 4 Latin squares with a 2 × 2 factorial arrangement of treatments. Diets contained low (LF; 45% of diet DM) or high forage (HF; 65% of diet DM) and YMP at 0 (NYMP) or 2.
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