AI Article Synopsis
- - The study investigates how Methylphenidate influences state-anxiety in healthy individuals, utilizing a cross-over design with 36 participants who received either the medication or a placebo.
- - Overall, Methylphenidate did not show a significant effect on state-anxiety for the group, but individuals with higher initial anxiety reported a notable reduction in anxiety levels after taking the medication.
- - A strong negative correlation was found between initial anxiety levels and the change in state-anxiety, indicating the medication's effects may depend on the individual's anxiety state rather than attention levels.
Article Abstract
Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.psychres.2016.05.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adverse events and safety concerns among university students who misused stimulants to increase academic performance.
Einstein (Sao Paulo)
December 2024
Faculdades Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil.
Article Synopsis
- - The study evaluated psychostimulant drug use among 389 health-related university students in Minas Gerais, Brazil, revealing a 21% prevalence, primarily among men, medicine, and psychology students.
- - Methylphenidate was the most commonly used drug, with many students using it without a prescription; 65% reported having a medical diagnosis, but many did not have valid indications for use.
- - The findings highlight significant risks associated with psychostimulant use, including side effects and drug interactions, emphasizing the need for educational policies to prevent inappropriate usage among students.
Methylphenidate abuse and misuse in patients affected with a psychiatric disorder and a substance use disorder: a systematic review.
Front Psychiatry
November 2024
Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University, Chieti, Italy.
Article Synopsis
- - Methylphenidate (MPH), often used to treat ADHD, is increasingly misused by individuals with co-occurring psychiatric and substance use disorders, raising concerns about dependence and adverse effects.
- - A systematic review conducted in 2024 analyzed 12 studies, focusing on patterns of MPH misuse among patients with various psychiatric disorders, including conduct, mood, and anxiety disorders.
- - The results showed a significant correlation between MPH misuse and individuals with psychiatric disorders, particularly those also suffering from Alcohol Use Disorder, highlighting the need for targeted interventions and monitoring.
Asymmetry of attentive networks contributes to adult Attention-deficit/hyperactivity disorder (ADHD) pathophysiology.
Eur Arch Psychiatry Clin Neurosci
November 2024
Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
Diffusion imaging studies in Attention-deficit/hyperactivity disorder (ADHD) have revealed alterations in anatomical brain connections, such as the fronto-parietal connection known as superior longitudinal fasciculus (SLF). Studies in neurotypical adults have shown that the three SLF branches (SLF I, II, III) support distinct brain functions, such as attention and inhibition; and that their pattern of lateralization is associated with attention performance. However, most studies in ADHD have investigated the SLF as a single bundle and in children; thus, the potential contribution of the lateralization of the SLF branches to adult ADHD pathophysiology remains to be elucidated.
View Article and Find Full Text PDFRisk of Incident Psychosis and Mania With Prescription Amphetamines.
Am J Psychiatry
October 2024
Division of Psychotic Disorders, McLean Hospital, Belmont, MA (Moran, Shinn, Nielsen, Cohen, Erkol, Merchant, Mujica, Ongur); Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston (Moran, Skinner); Department of Psychiatry, Harvard Medical School, Boston (Moran, Shinn, Rao, Taylor, Perlis, Ongur); Department of Psychiatry, Massachusetts General Hospital, Boston (Rao, Taylor, Perlis).
Article Synopsis
- A recent study investigated the relationship between prescription amphetamines and the risk of developing psychosis or mania, finding that amphetamine use has increased in the U.S. over the past years.
- The research used case-control methods, comparing hospitalized patients with psychosis against those hospitalized for other psychiatric issues, and identified a significant link between higher doses of amphetamines and increased odds of these serious mental health outcomes.
- The findings highlight the need for cautious prescribing practices, particularly for high doses of amphetamines, along with ongoing monitoring for signs of psychosis or mania in patients.
Case Report: Methylphenidate and venlafaxine improved abdominal nociplastic pain in an adult patient with attention deficit hyperactivity disorder, autism spectrum disorder, and comorbid major depression.
Front Pain Res (Lausanne)
August 2024
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
Introduction: Nociplastic pain (NP), classified as a third type of pain alongside nociceptive and neuropathic pain, is chronic pain arising from the amplification of nociceptive stimuli through central sensitization, despite the absence of tissue damage, sensory nerve damage, or disease. An important clinical feature of NP is that it is not only associated with pain but also with sensory hypersensitivity to sound and light and cognitive dysfunction, including mood and attention disorders. Recent studies have suggested that depression and developmental disorders, such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), coexist with NP at high frequency.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!