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Article Synopsis
- Antimicrobial resistance (AMR) is a significant global health issue in the 21st century, affecting the burden of disease and mortality linked to bacterial infections across various regions.
- A comprehensive study was conducted to assess the impact of AMR from 1990 to 2021, analyzing data from 204 countries on deaths and disability-adjusted life years (DALYs) related to 22 pathogens and 84 pathogen-drug combinations.
- The researchers employed statistical modeling and extensive datasets to estimate AMR's burden, even in areas lacking direct data, considering multiple factors such as sepsis-related deaths and antibiotic resistance rates.
The relationship between lactate dehydrogenase to albumin ratio and all-cause mortality during ICU stays in patients with sepsis: A retrospective cohort study with propensity score matching.
Heliyon
March 2024
Department of Intensive Care Unit, Huzhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Affiliated Central Hospital Huzhou University, Huzhou, 313000, China.
Background: Sepsis is a prevalent and severe medical condition which is frequently observed in the intensive care unit (ICU). Although numerous biomarkers have been identified to predict the prognosis of sepsis, the lactate dehydrogenase to albumin ratio (LDH/ALB ratio) has not been extensively investigated. The principal objective of this study is to assess the relationship between LDH/ALB ratio and all-cause mortality in patients with sepsis.
View Article and Find Full Text PDFArticle Synopsis
- The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force worked on creating and validating new clinical criteria for identifying pediatric sepsis and septic shock, focusing on organ dysfunction metrics.
- This research involved a large-scale international study across 10 healthcare systems, collecting data on nearly 3.6 million children over nine years to derive and test the new criteria.
- The final scoring system, named the Phoenix Sepsis Score, was developed from a 4-organ-system model, demonstrating varying effectiveness in predicting mortality through different performance metrics during validation.
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial.
JAMA
July 2023
Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Importance: Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermittent administration, continuous administration of meropenem may improve clinical outcomes.
View Article and Find Full Text PDFEffect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial.
JAMA Intern Med
July 2023
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Article Synopsis
- Recent research has indicated that Xuebijing injection (XBJ), an herbal intravenous treatment, may lower death rates in sepsis patients.
- The EXIT-SEP trial, involving 1817 patients in 45 intensive care units, aimed to assess the effect of XBJ versus a placebo on 28-day mortality in sepsis patients.
- Results showed a significant reduction in mortality for those receiving XBJ compared to placebo, meaning XBJ could be a promising treatment option for sepsis.
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