Short and scalable synthesis of the complex pentacyclic indolosesquiterpene natural product mycoleptodiscin A has been achieved from commercially available diterpenoid (+)-sclareolide in 19% overall yield. This approach allows one to prepare various analogues of mycoleptodiscin using McMurry cyclization as a key reaction with just three chromatographic purifications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.6b01145 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The European regulatory system for plant protection products-cause of a "Silent Spring" or highly advanced and protective?
Integr Environ Assess Manag
January 2025
Industrieverband Agrar e. V. (IVA), Wissenschaft und Innovation, Frankfurt am Main, Germany.
Current publications that are shaping public perception repeatedly claim that residues of plant protection products (PPP) in the environment demonstrate gaps in assessing the exposure and effects of PPP, allegedly revealing the inability of the European regulatory system to prevent environmental contamination and damage such as biodiversity decline. The hypothesis is that environmental risk assessments rely on inappropriate predictive models that underestimate exposure and do not explicitly account for the impact of combinations of environmental stressors and physiological differences in stress responses. This article puts this criticism into context to allow for a more balanced evaluation of the European regulatory system for PPP.
View Article and Find Full Text PDFMining versatile feruloyl esterases: phylogenetic classification, structural features, and deep learning model.
Bioresour Bioprocess
January 2025
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biological and Environment Engineering, Zhejiang Shuren University, Hangzhou, 310015, China.
Feruloyl esterases (FEs, EC 3.1.1.
View Article and Find Full Text PDFTccP4: a novel effector identified in the strain 1551-2 required for attaching and effacing lesion formation on infected Nck-null cells.
Microbiol Spectr
January 2025
Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.
is a pathogen that causes sporadic cases and outbreaks of diarrhea. The main virulence feature of this bacterium is the attaching and effacing (AE) lesion formation on infected intestinal epithelial cells, which is characterized by the formation of pedestal-like structures that are rich in F-actin. The Brazilian 1551-2 strain can recruit F-actin using both the Nck-dependent and the Nck-independent pathways, the latter of which uses an adaptor protein named Tir-cytoskeleton coupling protein (TccP/EspF).
View Article and Find Full Text PDFLitR and its quorum-sensing regulators modulate biofilm formation by .
J Bacteriol
January 2025
Department of Microbiology and Immunology, Stritch School of Medicine Loyola University Chicago, Chicago, Illinois, USA.
Quorum sensing controls numerous processes ranging from the production of virulence factors to biofilm formation. Biofilms, communities of bacteria that are attached to one another and/or a surface, are common in nature, and when they form, they can produce a quorum of bacteria. One model system to study biofilms is the bacterium , which forms a biofilm that promotes the colonization of its symbiotic host.
View Article and Find Full Text PDF<b>Background and Objective:</b> Peatlands are unique ecosystems rich in microbial diversity, including bacteria with potential antibiotic activity. This study focuses on the isolation and characterization of bacteria from Indonesian peat soil, particularly their potential to produce antibiotics against multidrug-resistant (MDR) pathogens, including Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA). <b>Materials and Methods:</b> Bacterial isolates were rejuvenated on nutrient agar and subjected to antimicrobial activity testing using the Bauer & Kirby diffusion method against MRSA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!