AI Article Synopsis
- Two cases of tubulosquamous polyps in the vagina were examined, showing specific immunohistochemical markers like GATA3 and NKX3.1, with implications for their origin.
- The study also included comparisons with cervical squamous cysts thought to be ectopic prostatic tissue and Skene-type glands, contributing to a better understanding of these conditions.
- The authors propose that vaginal Brenner tumors and tubulosquamous polyps may be the same and recommend NKX3.1 as a preferred marker for diagnosing these types of tissue.
Article Abstract
Two tubulosquamous polyps arising in the vagina are reported. Both were diffusely positive for GATA3 in the squamous component and focally positive for NKX3.1 in the glandular component, prostate acid phosphatase was focally positive in only 1 case in the glandular component. Both cases were negative for PAX2, PAX8, SALL4, and prostate-specific antigen. In addition, we included 3 cases of cervical squamous-lined cysts most likely representing ectopic prostatic tissue in the cervix and 1 case of paraurethral Skene-type glands to compare the immunophenotype. We analyze this immunoprofile, not previously reported. We also suggest unifying the nomenclature because vaginal Brenner tumors are most likely synonymous with tubulosquamous polyp (TSP) of the vagina. Our findings add support to the postulated origin of TSPs and cervical ectopic prostatic tissue from eutopic or misplaced Skene glands, equivalent of the prostate in the female. NKX3.1 seems a better marker to study and diagnose ectopic prostatic tissue in the cervix as well as TSPs.
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| http://dx.doi.org/10.1016/j.anndiagpath.2016.04.005 | DOI Listing |
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