Cushing's syndrome (CS) is associated with cardiovascular disease. The impact of the hemodynamic load on left ventricular mass (LVM) in patients with CS is not well known. In fact, the effects of 24-h blood pressure (BP) load and BP circadian rhythm on cardiac structure and function have not been studied. Aim of the present study has thus been to assess the presence of cardiac remodeling in patients with newly diagnosed CS, combining evaluation of cardiac remodeling and assessment of BP burden derived by 24-h ambulatory blood pressure monitoring (ABPM). 25 patients (4 M, 21 F) with CS underwent echocardiography in order to assess cardiac morphology and geometry (relative wall thickness-RWT). As controls, 25 subjects similar for demographic characteristics and 24-h BP were used. CS Patients were similar to controls by age, sex, mean 24-h BP, and body mass index. There was a significant increase in left ventricular mass (LVM; 44.4 ± 14.7 vs. 36.9 ± 10 g/m, p = 0.03) and a significant increase in RWT (0.46 ± 0.07 vs. 0.41 ± 0.08, p = 0.02) in CS patients compared to controls. The prevalence of CS patients with pressure non-dipping profile was greater than that of controls (56 vs. 16 %, p < 0.05), with no significant association with LVM or geometry. 24-h urinary cortisol was not associated with LVM (r = 0.1, p = 0.5) or RWT (r = 0.02, p = 0.89) in the CS group. In conclusion, LVM and the concentric pattern of the left ventricle are relatively independent from 24-h BP load and profile (dipping/non-dipping) in CS patients.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s12020-016-0986-6 | DOI Listing |
Introduction: Chronic ischemic heart failure is a major global health issue despite advancements in therapy. Stem cell (SC) therapy has emerged as a potential treatment, but its effectiveness remains uncertain. This study aimed to systematically review and meta-analyze the current evidence on SC therapy's efficacy.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Department of Cardiology, University of Giessen, Giessen, Germany.
We report a case of spontaneous coronary dissection (SCAD) in a 32-year-old pregnant patient during the seventh month of her second pregnancy. A 32-year-old pregnant woman in the 28th week of gestation was referred to our intensive care unit because of angina as well as elevated troponin levels. The initial electrocardiogram and transthoracic echocardiogram (TTE) were normal.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Mécénat Cardiac Surgery, Paris, France.
Anatomically corrected malposition (ACM) of the great arteries is an exceedingly rare congenital heart disease. This conotruncal anomaly manifests with an L-malposition of the aorta (situs solitus, D loop, aorta to the left of the pulmonary artery) with normal ventriculoarterial concordance. A 14-month-old boy presented with an ACM associated with a ventricular septal defect that was successfully repaired.
View Article and Find Full Text PDFJACC Case Rep
January 2025
AIIMS Rishikesh, Rishikesh, Uttarakhand, India.
Myxoma is a cardiac tumor most commonly found in the left atrium, presenting most frequently with dyspnea, chest pain, and constitutional symptoms. Hereby, we are presenting a rare case of cardiac myxoma originating from the left ventricle, presenting with an ischemic stroke in a young individual. He underwent surgical excision of the mass.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
We present a first in human experience of transseptal balloon-assisted translocation of a mitral anterior leaflet (BATMAN) to facilitate transcatheter mitral valve replacement in a patient with severe mitral annular calcification who was at high risk of left ventricular outflow tract obstruction.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!