AI Article Synopsis
- Preclinical animal models are crucial for advancing adoptive immunotherapies in cancer treatment by allowing researchers to study how transferred immune cells behave in a living organism.
- Understanding where these cells travel in the body (biodistribution) helps link their behavior to treatment success and can guide strategies to improve their targeting to tumors.
- This chapter outlines a straightforward method for labeling NK cells with fluorescence for imaging in small animal models, enhancing tracking of these cells during research.
Article Abstract
Preclinical animal models play a vital role in developing novel adoptive immunotherapies for cancer. In these in vivo models, it is essential to track the adoptively transferred cells to understand their tissue localization (biodistribution) in order to correlate with observed therapeutic outcomes as well as to develop novel approaches to promote homing to tumors or organs of interest. This chapter describes a simple and quick method for fluorescence labeling and in vivo imaging of adoptively transferred NK cells in small animal models.
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| http://dx.doi.org/10.1007/978-1-4939-3684-7_26 | DOI Listing |
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