Background: Flashlamp-pumped pulsed (FLPP) dye laser still represents the standard treatment for the majority of port wine stains (PWSs), but the results on thick PWSs remain unpredictable, and many of these lesions fail to completely respond. Our aim was to report on the results obtained on unresponsive PWSs to standard laser treatments, by using a double phase laser treatment strategy using two laser passes in the same session.
Methods: Eleven adult patients with facial PWS resistant to dye laser were enrolled. Laser sessions were scheduled every 8 weeks, and each of them consisting of two laser passes. In phase one, two different laser wavelengths (595 nm and 1064 nm) were delivered consecutively to each affected area. In the second phase, the PWS was treated using a pulse stacking technique with the 1064 nm Nd:YAG.
Results: One patient was lost to follow-up. Among the remaining ten, 5 (50%) patients showed an excellent improvement (>75%), 3 (30%) patients showed a good improvement (51-75%), and 2 (20%) patients had no or minimal improvement (0-25%).
Conclusions: Our results suggest that the combination of different wavelengths in the same session can be helpful for PWSs resistant to standard laser treatments. However, in most patients two treatment phases were necessary.
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Blood
January 2025
Cleveland Clinic, Cleveland, Ohio, United States.
Antibodies to β2-glycoprotein I (β2GPI) cause thrombosis in antiphospholipid syndrome, however the role of β2GPI in coagulation in vivo is not understood. To address this issue, we developed β2GPI-deficient mice (Apoh-/-) by deleting exon 2 and 3 of Apoh using CRISPR/Cas9 and compared the development of thrombosis in wild-type (WT) and Apoh-/- mice using rose bengal and FeCl3-induced carotid thrombosis, laser-induced cremaster arteriolar injury, and inferior vena cava (IVC) stasis models. We also compared tail bleeding times and activation of platelets from WT and Apoh-/- mice in the absence and presence of β2GPI.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Department of Earth System Sciences, Center for Earth System Research and Sustainability, University of Hamburg, Hamburg 20146, Germany.
As an essential micronutrient, phosphorus plays a key role in oceanic biogeochemistry, with its cycling intimately connected to the global carbon cycle and climate change. Authigenic carbonate fluorapatite (CFA) has been suggested to represent a significant phosphorus sink in the deep ocean, but its formation mechanisms in oceanic low-productivity settings remain poorly constrained. Applying X-ray absorption near edge structure, transmission electron microscopy, and laser ablation inductively coupled plasma mass spectrometer analyses, we report a unique mineral assemblage where CFA crystals coat phillipsite in abyssal sediments of the East Mariana Basin and the Philippine Sea.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
DWI─Leibniz Institute for Interactive Materials e.V., Forckenbeckstraße 50, Aachen 52074, Germany.
The global dental implant market is projected to reach $9.5 billion by 2032, growing at a 6.5% compound annual growth rate due to the rising prevalence of dental diseases.
View Article and Find Full Text PDFRev Esc Enferm USP
January 2025
Universidade Federal de Viçosa, Departamento de Medicina e Enfermagem, Viçosa, MG, Brazil.
Objective: To compare the effectiveness of ear acupuncture with laser and needles in the treatment of anxiety in university students in the post-pandemic context of Covid-19, as well as to evaluate the possible symptoms or adverse reactions triggered by the interventions.
Method: Randomized clinical trial carried out with 126 university students, allocated to the "Needle" (control) and "Laser" (experimental) groups. Five ear acupuncture sessions were performed.
ACS Sens
January 2025
School of Chemistry and Molecular Engineering, In Situ Devices Research Center, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, Shanghai 200241, China.
Monitoring volatile organic compounds (VOCs) is crucial for ensuring safety and health. In this study, we introduce a strategy to engineer a chromatography-inspired single-sensor (CISS) e-nose tailored for VOC monitoring. This approach overcomes the limitations of traditional methodologies and conventional e-noses.
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