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Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH-wildtype.
Brain Pathol
December 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- Adult primary leptomeningeal gliomatosis (PLG) is a rare and aggressive disease that affects the meninges with glial tumor infiltration but no obvious brain mass, and it has not been thoroughly studied at the molecular level.
- In a study of six PLG patients, all showed leptomeningeal enhancement; most were diagnosed via biopsy revealing astrocytic gliomas with notable genetic mutations, including IDH-wildtype and TERT promoter alterations, which indicated similarities to adult-type glioblastoma.
- All patients unfortunately died from the disease, with a median survival of just 24 days after diagnosis, although one case with early intervention survived significantly longer, suggesting that early detection and treatment may
Clinico-Pathological Features of Diffuse Midline Glioma, H3 K27-Altered in Adults: A Comprehensive Review of the Literature with an Additional Single-Institution Case Series.
Diagnostics (Basel)
November 2024
Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy.
Diffuse midline glioma (DMG), H3 K27-altered, is a WHO grade 4 malignant glioma located at midline structures, including the thalamus, brainstem and spinal cord. While H3 K27-altered DMG is more common in pediatric age in which it shows a uniformly aggressive clinical behavior, its occurrence is relatively unusual among adults, and its clinico-pathological and prognostic features are not fully characterized in this age group. In this present paper, a review of the literature, including all cases of adult H3 K27-altered DMG published from January 2010 to December 2023 was performed, and the following clinical parameters were evaluated: sex, age (median and range), anatomic site, median follow-up, leptomeningeal dissemination, local recurrence and treatment.
View Article and Find Full Text PDFAre Dinucleotide Alterations Definitional for Myxoid Glioneuronal Tumor? Report of p. K385L Mutation in a Neonatal High-Grade Glioma.
Pediatr Dev Pathol
December 2024
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tumors are increasingly defined by molecular alterations but approach to cases with discordant histologic and molecular features is unclear. Myxoid glioneuronal tumor (MGNT), histologically similar to dysembryoplastic neuroepithelial tumor (DNET), is characterized by dinucleotide mutations in gene (K385L or K385I). Here, we report K385L mutation in a neonatal high-grade glioma.
View Article and Find Full Text PDFHigh-grade astrocytoma with piloid features in the conus medullaris: a rare presentation of a new World Health Organization diagnosis. Illustrative case.
J Neurosurg Case Lessons
October 2024
Georgia Neurosurgical Institute, Macon, Georgia.
Article Synopsis
- Neuroepithelial tumors resembling pilocytic astrocytoma have been reclassified by the WHO as high-grade astrocytoma with piloid features (HGAP), highlighting their unique characteristics and rarity.
- An 83-year-old woman experienced progressive lower-extremity weakness, leading to the discovery of a neuroepithelial tumor in the conus medullaris, which is an uncommon site for this type of tumor.
- The case emphasizes the need for clinicians to consider HGAP in differential diagnoses for spinal cord masses, as it represents a novel classification of a rare condition.
A case of epithelioid glioblastoma with lung metastases in a young Cane Corso dog.
J Comp Pathol
November 2024
Institute of Infection, Veterinary and Ecological Sciences, Department of Veterinary Anatomy, Physiology and Pathology, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Astrocytomas are relatively common primary brain tumours of humans and companion animals. In dogs, they represent approximately 17-28% of primary central nervous system tumours. However, extracranial metastasis is extremely rare.
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