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| http://dx.doi.org/10.1164/rccm.201512-2541ED | DOI Listing |
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Article Synopsis
- The study investigates how Benzo[a]pyrene (BaP), an environmental pollutant, affects the progression of nonalcoholic fatty liver disease (NAFLD) through its interaction with the AHR/ERα axis.
- In experiments using high-fat diet models and Oleic acid treatment on HepG2 cells and C57BL/6J mice, exposure to BaP was found to inhibit ERα protein levels and disrupt lipid metabolism, evidenced by changes in key biomarkers (CYP1A1, SREBP-1c).
- The presence of estradiol (E2) can mitigate some negative effects of Oleic acid on lipid accumulation; however, BaP reduces the beneficial effects of E
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