The authors advance the case of a patient aged 42, with cardiovascular disorders who is hospitalized for non-specific, but persistent symptomatology: asthenia, fatigability, dyspnoea, night sweats. The clinical (splenomegaly), abdominal ultrasonographic (splenic hypo-echogenic lesions) and computed tomographic (splenic hypo-dense lesions) elements lead to a splenic disorder, but the association of intra-thoracic and intra-abdominal adenopathies(CT revealed) raises suspicion of a chronic lymphoproliferative syndrome. Splenectomy by open approach is performed and the surprise comes from histopathology: splenic tuberculosis. Clinical, diagnostic and therapeutic aspects of tuberculosis with splenic localization are presented.

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