AI Article Synopsis
- About 70% of community-acquired acute kidney injury cases are due to pre-renal causes, often with normal kidney function.
- Reduced kidney blood flow, often from low blood volume or decreased blood pressure, can lead to a lower glomerular filtration rate (GFR).
- In patients with existing chronic kidney disease, the body's ability to adjust renal blood flow is weakened, increasing their risk of acute-on-chronic renal failure.
Article Abstract
Approximately 70% of community-acquired cases of acute kidney injury are attributed to pre-renal causes. In most of these cases, the underlying kidney function may be normal, but decreased renal perfusion associated with low intravascular volume or decreased arterial pressure can determine a reduced glomerular filtration rate (GFR). Autoregulatory mechanisms can partially compensate renal perfusion reduction in order to maintain GFR. In patients with pre-existing chronic kidney disease, however, these mechanisms are impaired, and the susceptibility to develop acute-on-chronic renal failure is higher.
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| http://dx.doi.org/10.1159/000445462 | DOI Listing |
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