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Cerebellar asymmetries.
Handb Clin Neurol
March 2025
Western Institute for Neuroscience, Western University, London, ON, Canada; Department of Computer Science, Western University, London, ON, Canada; Department of Statistical and Actuarial Sciences, Western University, London, ON, Canada.
The cerebellum is a subcortical structure tucked underneath the cerebrum that contains the majority of neurons in the brain, despite its small size. While it has received less attention in the study of brain asymmetries than the cerebrum, structural asymmetries in the cerebellum have been found in cerebellar volume that mirror cerebral asymmetries. Larger cerebellar structures have been reported on the right compared to the left, either for the whole cerebellar hemisphere or the anterior part of the cerebellum, with the latter accompanied by a left increase in the posterior cerebellum.
View Article and Find Full Text PDFThe development of the Postdoctoral Nurses Competence Scale: A Delphi consensus and content validity study.
J Prof Nurs
March 2025
Nursing Science department, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands; Nursing Science, Program in Clinical Health Sciences, University Medical Center Utrecht, Utrecht, the Netherlands.
Background: PhD prepared nurses advance nursing science through research and integration of findings into practice. They demonstrate expertise in research, education, patient care, and policy. Various professional competencies are required for success in research, clinical practice, and education.
View Article and Find Full Text PDFResearch quality and dissemination of paediatric randomised controlled trials with and without patient and family engagement: systematic review.
BMJ Open
March 2025
Division of Paediatric Medicine and Paediatric Outcomes Research Team (PORT), The Hospital for Sick Children, Toronto, Ontario, Canada.
Objectives: Authentic patient and family engagement in child health research is defined as researchers working in partnership with patients and families on all aspects of the research process, including refining the research question, tailoring the intervention, devising study procedures and disseminating study findings. While there is good evidence of a positive impact of patient engagement on the research process, on research teams and on patient partners, there are few empirical data on the impact of patient and family engagement on research quality and dissemination. We conducted a systematic review to compare research quality and dissemination metrics for paediatric randomised controlled trials (RCTs) that engaged patients and families in the research process with trials that did not.
View Article and Find Full Text PDFWhat the clinician should know when ordering a mast cell tryptase test: A review article for the North American practicing clinician.
Ann Allergy Asthma Immunol
March 2025
University Hospital of Reims, Immunology Laboratory, Biology and Pathology Department, Reims, France; University of Reims Champagne-Ardenne, INSERM UMR 1250, Reims, France. Electronic address:
Tryptase is currently the most specific mast cell biomarker available in clinical laboratories. Tryptase levels in peripheral blood contribute to the diagnostic, prognostic and therapeutic evaluation of three clinical categories: (1) immediate hypersensitivity reactions including the life-threatening systemic form known as anaphylaxis, (2) clonal mast cell diseases and other myeloid malignancies, including as a biomarker for efficacy of chemotherapeutic agents targeting mast cell survival, and (3) hereditary α-tryptasemia (HαT), a genetic trait found in 4 - 8% of general population associated to increased risk of severe immediate hypersensitivity reactions. Rapidly evolving pathophysiology knowledge and management guidelines impact tryptase use in clinical practice, explaining the need for frequent updates.
View Article and Find Full Text PDFTransfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults An American College of Chest Physicians Clinical Practice Guideline.
Chest
March 2025
Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.
Background: Platelets and fresh frozen plasma (FFP) are frequently administered to critically ill patients. Considering the variability in indications and thresholds guiding these transfusions, a comprehensive review of current evidence was conducted to provide guidance to critical care practitioners. This CHEST guideline examined the literature on platelet transfusions in critically ill patients with thrombocytopenia, with and without active bleeding, as well as data on prophylactic platelet and FFP transfusions for common procedures in the critical care setting.
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