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[Ubiquilin-2 immunostaining - a new marker as a diagnostic supplement in urine cytology?].
Urologe A
June 2016
Klinik für Urologie, Uroonkologie und Kinderurologie, Universitätsklinik Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Ubiquilin2 as a novel marker for detection of urothelial carcinoma cells in urine.
Diagn Cytopathol
January 2016
Department of Pathology, Nara Medical University School of Medicine, 840 Shijo-Cho, Kashihara City, Nara, 634-8521, Japan.
Background: Ubiquilin 2 (UBQLN2), an ubiquitin-related protein, is strongly expressed in urothelial carcinoma cells, in contrast to no or less expression in non-neoplastic cells; it protects cancer cells from reactive oxygen species (ROS)-induced cytotoxicity. In this study, we investigated whether UBQLN2 immunostaining, using liquid-based cytology sample could improve the accuracy of cytological urine diagnosis.
Methods: Two-hundred and forty-five urinary samples, including 143 negative controls and 102 urothelial carcinomas, consisting of 42 low-grade and 60 high-grade urothelial carcinomas, were used for immunocytochemical analysis of UBQLN2.
UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis.
Neurobiol Aging
October 2012
Northcott Neuroscience Laboratory, ANZAC Research Institute, Sydney, New South Wales, Australia.
Amyotrophic lateral sclerosis (ALS) shows clinical and pathological overlap with frontotemporal dementia that includes the presence of hallmark ubiquitinated inclusions in affected neurons. Mutations in UBQLN2, which encodes ubiquilin 2, were recently identified in X-linked juvenile and adult-onset ALS and ALS/dementia. As part of an established exome sequencing program to identify disease genes in familial ALS, we identified a novel missense UBQLN2 mutation (c.
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