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Neural stem cell-derived extracellular vesicles purified by monolith chromatography retain stimulatory effect in in vitro scratch assay.
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Institute of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address:
Background Aims: Extracellular vesicles (EVs) have gained traction as potential cell-free therapeutic candidates. Development of purification methods that are scalable and robust is a major focus of EV research. Yet there is still little in the literature that evaluates purification methods against potency of the EV product.
View Article and Find Full Text PDFSupporting Primary Care Providers to Improve Adolescent Behavioral and Mental Health.
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Behavioral and mental health (BMH) issues are increasing in adolescents as shortages of primary care and BMH providers are also rising. The healthcare burden has fallen especially hard on primary care providers (PCPs), who are showing increasing signs of burnout and making plans to reduce their work hours or leave the profession altogether. These factors impede their ability to be the first line of defense in providing emotional support to children and families.
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Department of ECE, Kallam Haranadhareddy Institute of Technology, Guntur, Andhra Pradesh, India.
Cognitive load stimulates neural activity, essential for understanding the brain's response to stress-inducing stimuli or mental strain. This study examines the feasibility of evaluating cognitive load by extracting, selection, and classifying features from electroencephalogram (EEG) signals. We employed robust local mean decomposition (R-LMD) to decompose EEG data from each channel, recorded over a four-second period, into five modes.
View Article and Find Full Text PDFA new sensor-less voltage and frequency control of stand-alone DFIG based dead-beat direct-rotor flux control-experimental validation.
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Electrical Engineering Department, Faculty of Engineering, Minia University, Minia 61111, Egypt. Electronic address:
The paper presents a new sensor-less voltage and frequency control method for a stand-alone doubly-fed induction generator (DFIG) feeding an isolated load. The proposed control approach directly regulates the magnitude and angle of the rotor-flux vector rather than controlling rotor currents or voltages as in classic field oriented control (FOC). To accurately regulate the magnitude and frequency of stator voltage, two separate closed-loop based PI regulators are employed to evaluate the reference signals of the rotor flux vector magnitude and angle, respectively.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances (PFAS) exposure is associated with radioiodine therapy resistance and dedifferentiation of differentiated thyroid cancer.
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State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:
Differentiated thyroid cancer (DTC) generally has a favorable prognosis, and radioactive iodine (RAI) therapy is typically used for metastatic DTC that continues to progress and poses life-threatening risks. However, resistance to RAI in metastatic DTC significantly impairs treatment effectiveness. This study aims to identify potential compounds that may influence RAI efficacy.
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