Angiomyofibroblastoma of the right labia major.

Indian J Pathol Microbiol

Department of Histology and Embryology, Namik Kemal University, Faculty of Medicine, Tekirdağ, Turkey.

Published: March 2017

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http://dx.doi.org/10.4103/0377-4929.182033DOI Listing

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Angiomyofibroblastoma of the right labia major.

Indian J Pathol Microbiol

March 2017

Department of Histology and Embryology, Namik Kemal University, Faculty of Medicine, Tekirdağ, Turkey.

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Article Synopsis
  • Vulvar angiomyofibroblastoma is a rare, benign tumor, reported in a 49-year-old woman, that appears in the vulvar area and was mistaken for a Bartholin cyst due to similar symptoms.
  • The tumor, measuring 3.5 cm, is encapsulated and presents a whitish, fleshy appearance with a myxoid texture, featuring a mix of dense and loose cellular areas that resemble a hemangiopericytoma pattern.
  • Histological analysis shows a proliferation of thin-walled blood vessels and various cell types; the tumor's immunoprofile suggests a myofibroblastic origin, despite the absence of certain muscle markers.
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Angiomyofibroblastoma of the vulva.

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Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Angiomyofibroblastoma (AMFB) is an uncommon benign mesenchymal tumor. AMFB occurs almost in the vulvo-vaginal area of women. The gross features of AMFB are well-circumscribed so it clinically is often thought as Bartholin gland cyst or aggressive angiomyxoma.

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Objective: Angiomyofibroblastoma (AMF) is a benign mesenchymal tumor usually found in the vulva. We reviewed 70 cases of vulvar AMF that have been reported in the English-language literature and report 1 case of a pedunculated variant. Our case brings the total reported to 71 and is only the fourth pedunculated variant reported.

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Angiomyofibroblastoma (AMFB) is a rare benign mesenchymal tumour that occurs almost exclusively in the vulvovaginal region of women but can also occur occasionally in the inguinoscrotal region of men. It is a well-circumscribed lesion that clinically is often thought to represent a Bartholin's gland cyst and usually does not form a pedunculated mass. To our knowledge, only five cases of vulvar AMFB with pedunculated mass have been reported in the English literature and all cases involving the labia majora and middle-aged women.

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