Necrotizing sialometaplasia is a rare benign and self-limiting disease, which commonly affects the minor salivary glands. Typically, it involves the seromucinous glands located at palate, buccal mucosa, tongue, tonsil, nasal cavity, trachea, larynx, maxillary sinus, and retromolar trigone. We report two such cases of necrotizing sialometaplasia to create awareness among the pathologists and surgeons because of its close morphological and clinical resemblance to squamous cell carcinoma. We have also documented that, the ischemic necrosis of salivary gland is the result of a vasculitic process.
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TGF-β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia.
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Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan.
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- - Necrotising sialometaplasia (NSM) is a non-cancerous growth mostly found in the minor salivary glands, presenting as swelling and potentially ulceration, often mimicking cancer like squamous cell carcinoma.
- - Histopathologically, NSM is characterized by lobular structures, acinar infarction, and changes in the salivary ducts, with an unknown cause that requires careful distinction from malignant conditions.
- - The study investigates the role of the TGF-β3 gene, finding that it is upregulated in NSM and may contribute to the condition by inhibiting cell growth and causing cell type changes during healing and tissue regeneration.
Necrotizing sialometaplasia on the hard palate after sequential induced vomiting: case study.
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Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
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- * The condition usually affects minor salivary glands, particularly in the hard palate, but can occur in other areas with salivary tissue.
- * Local ischemia, often caused by dental procedures and anesthesia in the palate, is believed to be the main factor behind this condition's development.
Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review.
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- Necrotizing sialometaplasia (NS) is a rare, self-limiting condition that mainly affects the minor salivary glands in the palate and is more common in men over 45 years old.
- *It typically appears as an ulcerative lesion but can also be non-ulcerated, making it critical to include in diagnoses when examining oral lesions.
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Simultaneous presentation of dual pathologies within the oral cavity: an unusual and diagnostically challenging presentation.
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- - Necrotising sialometaplasia (NS) is a rare condition with limited understanding of its causes and effects, making diagnosis complex and essential for ruling out oral cancer.
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