A 50-year-old male presented with cough and breathlessness. A positron emissoin tomography scan revealed FDG (Fluorodeoxyglucose) avid mediastinal mass. Tru-cut biopsy showed fibrotic stromal tissue with cellular infiltrate consisting of abnormal lymphoid cells and few large cells with smudged nucleus. Immunohistochemistry revealed diffuse positivity with CD20, focal positivity for CD30 and rare CD15 positive cells. Histological picture and immune profile showed overlaping features of non-Hodgkin's as well as Hodgkin's lymphoma. A diagnosis of mediastinal gray zone lymphoma was made. The patient showed a complete metabolic response to six cycles of chemotherapy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Primary mediastinal large B-cell lymphoma from the clinic to genomics: Insights for pathologists.
Hum Pathol
December 2024
American University of Beirut, Beirut, Lebanon. Electronic address:
Primary mediastinal large B-cell lymphoma (PMBL) is a mature aggressive B-cell lymphoma that arises in the anterior mediastinum, likely originating from thymic B cells. Initially considered a subtype of diffuse large B-cell lymphoma, PMBL has since been established as a distinct clinicopathologic entity due to its unique clinical, morphologic, immunophenotypic and genetic characteristics. PMBL primarily affects young adults, especially women, and manifests as a bulky mediastinal mass that can invade adjacent structures, often causing respiratory symptoms.
View Article and Find Full Text PDFThe Gray Area of Sarcoidosis and Tuberculosis: A Diagnostic Enigma.
Cureus
October 2024
Respiratory Medicine, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
This case report presents a challenging diagnostic enigma, where a 29-year-old male patient presented with symptoms and signs favoring both tuberculosis (TB) and sarcoidosis. The patient's plain chest radiograph showed bilateral hilar opacities, while a contrast-enhanced computed tomography (CECT) scan revealed multiple mediastinal and hilar lymph nodes. Histopathology of a mediastinal lymph node biopsy showed necrotizing granulomatous inflammation, favoring TB.
View Article and Find Full Text PDFGATA3 Immunohistochemical Staining in Classical Hodgkin Lymphoma and its Diagnostic Utility in Differential Diagnosis.
Turk J Haematol
October 2024
İstanbul University, İstanbul Faculty of Medicine, Department of Pathology, İstanbul, Türkiye.
Objective: Classical Hodgkin lymphoma (CHL) is a common lymphoid neoplasm with a wide range of differential diagnosis. Although it has a specific immunophenotype, aberrant expression of antigens can cause problems at its diagnosis. In this study we evaluated the usefulness of GATA3 in differential diagnosis of classical Hodgkin lymphoma.
View Article and Find Full Text PDFClinical Significance of Whole-Body Computed Tomography Scans in Pediatric Out-of-Hospital Cardiac Arrest Patients Without Prehospital Return of Spontaneous Circulation.
Diseases
October 2024
Department of Radiology, Tokyo Medical University Hospital, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Article Synopsis
- Whole-body computed tomography (WBCT) is used to screen pediatric patients following out-of-hospital cardiac arrest (OHCA) without prior return of spontaneous circulation (ROSC).
- A study analyzed 27 pediatric patients to assess the causes of OHCA and compare CT findings between those who achieved ROSC and those who did not, revealing significant differences in CT results.
- While no direct cause of OHCA was found in the WBCT, the non-ROSC group showed more concerning findings, which could help guide decisions about resuscitation efforts in similar cases.
Postoperative irradiation in stage II thymomas: is it worth it?-shedding some light in the guidelines' gray zone.
Updates Surg
October 2024
Division of Thoracic Surgery; Cardiac, Thoracic and Vascular Department, University Hospital of Pisa, Via Paradisa 2, 56100, Pisa, Italy.
Article Synopsis
- Thymomas are rare tumors that are usually treated surgically in early stages (I-II), but may require a team approach in more advanced stages (III-IV).
- This study analyzed data from 195 patients with stage II thymomas who underwent surgery between 2000 and 2020 to evaluate the effectiveness of postoperative radiotherapy (PORT) on disease-free survival (DFS).
- Results showed that PORT did not improve DFS for stage II thymomas, regardless of subtype or stage, suggesting that patients who have surgery for this condition may not benefit from additional local treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!