Treatment of Metastatic, Refractory Alveolar Soft Part Sarcoma: Case Reports and Literature Review of Treatment Options in the Era of Targeted Therapy.

J Pediatr Hematol Oncol

*Division of Pediatric Hematology-Oncology, Rady Children's Hospital-San Diego, University of California, San Diego, CA †Division of Pediatric Hematology-Oncology, St Joseph's Children's Hospital, Paterson, NJ ‡Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, NY.

Published: July 2016

Background: Alveolar soft part sarcoma is a rare soft tissue sarcoma that is characterized by a pattern of slow growth with metastases to the lung, bone, and brain that is not responsive to conventional cytotoxic chemotherapy.

Observations: We describe 2 patients, with a combined 19 years of treatment experience including multiple different chemotherapeutic and targeted therapy regimens, surgery, and radiotherapy. We also present a review of the literature regarding treatment options to highlight recent findings.

Conclusions: Alveolar soft part sarcoma is an indolent, but persistently progressive disease. Novel therapeutic agents hold promise in its management.

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http://dx.doi.org/10.1097/MPH.0000000000000571DOI Listing

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