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Inflammatory Signatures in VEXAS Syndrome, Myelodysplasia Cutis, and Sweet Syndrome.
JAMA Dermatol
March 2025
Service de Dermatologie et Allergologie, Faculté de Médecine, Sorbonne Université, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
Importance: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease caused by UBA1 somatic variants in hematopoietic progenitor cells, mostly involving adult men. It is associated with inflammatory-related symptoms, frequently involving the skin and hematological disorders. Recently described myelodysplasia cutis (MDS-cutis) is a cutaneous manifestation of myelodysplasia in which clonal myelodysplastic cells infiltrate the skin.
View Article and Find Full Text PDFCase Report: First report of pneumonia and organizing pneumonia in a patient with myelodysplastic and Sweet syndromes.
Front Immunol
March 2025
Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
The immunocompromised population is susceptible to pneumonia. The diagnosis and treatment of pneumonia in immunocompromised individuals are challenging clinical endeavors. Previous studies have identified pneumonia as a potential cause of organizing pneumonia (OP), however, the association between pneumonia and OP has not received enough clinical attention.
View Article and Find Full Text PDFNeutrophilic dermatosis of the dorsal hands (NDDH) is a localized variant of Sweet syndrome, a neutrophilic dermatosis commonly associated with underlying malignancy or systemic inflammatory disorders. NDDH can be mistaken for infection due to its rarity, clinical appearance, and common association with elevated inflammatory markers. A high index of suspicion for this diagnosis should be maintained with symmetrical hand lesions, as approximately 78% of patients with NDDH have bilateral disease.
View Article and Find Full Text PDFThe sensory system detects the internal and external environment of the body and the stimulus trigger feedback loops toward the set point to maintain homeostasis, but if taste sensitivity has changed, we may consume more nutrients or loss of appetite. These can lead metabolic syndrome or malnutrition, which can lead to frailty. In this review, we examined which of the five basic tastes (sweet, umami, bitter, sour, and salty) is affected by aging.
View Article and Find Full Text PDFSweet Syndrome With Painless Skin Lesions and Myopericarditis: A Case Report and Literature Review.
Clin Case Rep
March 2025
Department of Laboratory Medicine and Pathology Hamad Medical Corporation Doha Qatar.
Sweet syndrome is a rare inflammatory disease that typically presents with painful erythematous skin lesions and fever. Although the skin lesions are generally painful on clinical examination, in this case, they were noted to be painless without tenderness. Moreover, our case is unique in that this patient had myopericarditis, a rare extracutaneous manifestation of sweet syndrome.
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