Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224948 | PMC |
| http://dx.doi.org/10.1503/cmaj.151207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Convergent and Scalable Second-Generation Synthesis of the Fully Functionalized HIJKLMN-Ring Segment of Caribbean Ciguatoxin C-CTX-1.
J Org Chem
December 2024
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
A highly convergent and scalable second-generation synthesis of the fully functionalized HIJKLMN-ring segment of Caribbean ciguatoxin C-CTX-1, the primary toxin responsible for ciguatera fish poisoning in the Caribbean Sea and the Northeast Atlantic regions, has been accomplished. Key aspects of the synthetic approach include the efficient syntheses of the HI- and KLM-ring fragments on gram scales, a convergent fragment coupling toward the HIJKLM-ring skeleton based on the Suzuki-Miyaura coupling strategy, and optimized iron hydride-catalyzed hydrogen atom transfer-mediated olefin coupling conditions for constructing the N-ring.
View Article and Find Full Text PDFElectrochemical Biosensor for the Assessment of Cell Viability Using Methylene Blue. Application to the Detection of Ciguatoxins in Fish from the Canary Islands.
Anal Chem
December 2024
IRTA, Marine and Continental Waters, Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Cell-based biosensors (CBBs) for the detection of marine neurotoxins such as ciguatoxins (CTXs) are of high interest due to the composite toxicological response they can provide and the low limits of quantification (LOQs) they can achieve with the use of sensitive neural cells. However, the development and validation of CBBs are challenging due to the use of living material and the need for appropriate signal transduction strategies. In this work, Neuro-2a cells have been immobilized on thin-film gold electrodes, and their viability after exposure to CTX1B has been evaluated with light optical microscopy as well as cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using methylene blue (MB) as a redox indicator.
View Article and Find Full Text PDFMarine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological Vectors.
Mar Drugs
November 2024
Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Article Synopsis
- Harmful algal blooms (HABs) produce toxins that can cause serious illnesses in humans, including five main types of shellfish poisoning: DSP, PSP, ASP, NSP, and CP.
- These toxins primarily enter the human body through the consumption of contaminated fish and shellfish, and the prevalence of such toxin-related diseases is increasing globally.
- The paper reviews the toxic effects of these HABs on aquatic life and humans, aiming to better understand the mechanisms behind these toxins to reduce the health risks they pose.
[Identification of Fish Species Involved with Ciguatera Food Poisoning in Okinawan Waters by Using PCR-RFLP analysis].
Shokuhin Eiseigaku Zasshi
October 2024
Faculty of Science, University of the Ryukyus.
Ciguatera fish poisoning (CFP), known as a seafood-borne disease, is caused by consumption of fish contaminated with ciguatoxins in tropical and subtropical sea. The ciguatera fishes, Variola louti, Lutjanus monostigma and L. bohar have an absolute majority in the Ryukyu Archipelago, southwestern Japan.
View Article and Find Full Text PDFEpidemiology of Ciguatoxin Poisoning Outbreaks in the United States Between 2001 and 2021.
Foodborne Pathog Dis
October 2024
College of Population Health, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Article Synopsis
- This study analyzed data from the CDC's National Outbreak Reporting System on foodborne Ciguatoxin illnesses in the U.S. from 2001 to 2021, highlighting a lack of national understanding of these outbreaks.
- Previous research primarily focused on specific regions, revealing gaps in knowledge regarding the broader distribution and specific seafood responsible for Ciguatoxin poisoning.
- The findings indicate that the type of seafood consumed is significantly linked to hospitalization rates during outbreaks, suggesting that public health strategies should consider various factors, like the quantity and specific parts of the seafood involved.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!