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Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes.
Commun Biol
January 2025
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.
Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods.
View Article and Find Full Text PDFFirst-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer.
J Immunother Cancer
January 2025
Medical Oncology, Sarah Cannon Research Institute, Nashville, Tennessee, USA.
Background: SL-172154 is a hexameric fusion protein adjoining the extracellular domain of SIRPα to the extracellular domain of CD40L via an inert IgG-derived Fc domain. In preclinical studies, a murine equivalent SIRPα-Fc-CD40L fusion protein provided superior antitumor immunity in comparison to CD47- and CD40-targeted antibodies. A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.
View Article and Find Full Text PDFA ten-year prospective randomized trial comparing non-operative treatment to hook plate fixation for Rockwood III acromio-clavicular dislocation.
Orthop Traumatol Surg Res
January 2025
Faculté de médecine Université Laval, Pavillon Ferdinand-Vandry, 1050 avenue de la Médecine, Québec, Québec G1V 0A6, Canada; Département de chirurgie Université Laval, Pavillon Ferdinand-Vandry, 1050 avenue de la Médecine, Québec, Québec G1V 0A6, Canada; Centre de Recherche CHU de Québec Université Laval, Axe Médecine Régénératrice, 2705 Bd Laurier, Québec, QC G1V 4G2, Canada. Electronic address:
Background: Despite new modern surgical techniques, no short-term functional differences have been demonstrated between operative and non-operative treatment for acute acromio-clavicular (AC) dislocations Rockwood III-V. Few studies describe the long-term clinical and radiological results of these lesions. We aim to compare the one- and ten-year outcome of patients either treated non-operatively or with hook plate fixation for Rockwood III AC lesions.
View Article and Find Full Text PDFNovel Tryptophyllin Peptides from Physalaemus centralis Inhibit Oxidative Stress-Induced Endothelial Dysfunction in Rat Aorta Preparation.
Toxicon
January 2025
Applied Immunology and Morphology Research Centre, NuPMIA, Morphology Area, Faculty of Medicine, University of Brasília, UnB, Brasília, Distrito Federal, Brazil. Electronic address:
Amphibian skin is a rich source of molecules with biotechnological potential, including the tryptophyllin family of peptides. Here, we report the identification and characterization of two tryptophyllin peptides, FPPEWISR and FPWLLS-NH, from the skin of the Central Dwarf Frog, Physalaemus centralis. These peptides were identified through cDNA cloning and sequence comparison.
View Article and Find Full Text PDFStructural and Functional Glycosylation of the Abdala COVID-19 Vaccine.
Glycobiology
January 2025
Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, OX1 3QU, United Kingdom.
Abdala is a COVID-19 vaccine produced in Pichia pastoris and is based on the receptor-binding domain (RBD) of the SARS-CoV-2 spike. Abdala is currently approved for use in multiple countries with clinical trials confirming its safety and efficacy in preventing severe illness and death. Although P.
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