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| http://dx.doi.org/10.5056/jnm16046 | DOI Listing |
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Regulation of erm(T) MLS phenotype expression in the emergent emm92 type group A Streptococcus.
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November 2024
Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.
In the last decade, invasive group A Streptococcus (iGAS) infections have doubled in the US, with equivalent increases in MLS (macrolide, lincosamide, and streptogramin B)-resistance. The emm92-type isolates carrying the erm(T) gene have been associated with an alarming emergence of iGAS infections in people who inject drugs or experience homelessness. Our goal was to elucidate the mechanisms behind inducible (iMLS) and constitutive (cMLS) resistance in emm92 isolates.
View Article and Find Full Text PDFA Rare Case of Erythromycin-Induced Rhabdomyolysis.
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Internal Medicine, Staten Island University Hospital, Staten Island, USA.
Rhabdomyolysis (RML) arises from the breakdown of muscle tissue, leading to the release of intracellular components into the bloodstream and potentially causing multi-organ failure. Multiple drugs have been reported to cause RML. We present here a rare instance of erythromycin-triggered RML in a patient who was not on any other potential RML-inducing medications.
View Article and Find Full Text PDFBackground: Group B streptococcus (GBS) causes neonatal invasive disease, mainly sepsis and meningitis. Understanding the clinical characteristics, laboratory tests, and antibiotic resistance patterns of GBS invasive infections provides reliable epidemiological data for preventing and treating GBS infections.
Methods: Clinical characteristics and laboratory test results from 86 patients with neonatal invasive disease (45 cases of early-onset disease [EOD] and 41 cases of late-onset disease [LOD]) recruited from Fujian Maternity and Child Health Hospital between January 2012 and December 2021 were analyzed.
Antibiotic Resistance in Vibrio Bacteria Associated with Red Spotting Disease in Sea Urchin (Echinodermata).
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November 2024
Israel Oceanographic and Limnological Research, The National Center for Mariculture, P.O. Box 1212, Eilat 8811201, Israel.
The red spotting disease harms sea urchins to the extent of mass mortality in the ocean and echinocultures, accompanied by environmental damage and economic losses. The current study emphasizes the antimicrobial resistance of three isolated bacteria, closely related to , , and , associated with red spotting in the cultured sea urchin . In vitro trials examined the susceptibility of these bacterial isolates to various antibiotics.
View Article and Find Full Text PDFAge-stratified analysis of adverse event signals for clarithromycin: a disproportionality analysis using the FDA Adverse Event Reporting System.
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College of Pharmacy, Jinan University, Guangzhou, Guangdong 511436, China.
Article Synopsis
- The study examines the adverse events (AEs) linked to clarithromycin, an antibiotic, across different age groups using data from the FDA Adverse Event Reporting System (FAERS).
- Common AEs include vomiting and diarrhea in younger age groups, while older adults experience issues like abnormal taste and drug interactions.
- Eighteen age-specific signals were identified, highlighting the need for tailored monitoring and management of clarithromycin's safety profile in different age demographics.
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