Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985521 | PMC |
| http://dx.doi.org/10.3238/arztebl.2016.0287b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation.
Aging Cell
January 2025
School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation.
View Article and Find Full Text PDFProbiotics as a targeted intervention in anti-ageing: a review.
Biomarkers
December 2024
College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan, PR China.
Article Synopsis
- * The review discusses how probiotics can influence gut microbiota and metabolism, potentially reducing cognitive decline and inflammation through mechanisms like the gut-brain axis.
- * Probiotics may serve as a targeted approach to restore gut health, potentially slowing down aging, managing age-related diseases, and improving overall quality of life.
Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.
Am J Audiol
September 2024
Department of Audiology and Speech-Language Pathology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Purpose: The primary objective of this study was to assess how age influences masseter vestibular evoked myogenic potential (mVEMP) parameters by utilizing 500-Hz tone burst stimuli delivered through air conduction.
Method: The study involved 110 participants ranging from 15 to 60 years of age, grouped into five categories, all of whom had no previous issues related to their vestibular system. The participants were exposed to 500-Hz tone burst stimuli at 125 dB SPL through ER-3A inserts.
Aging-related biomarker discovery in the era of immune checkpoint inhibitors for cancer patients.
Front Immunol
April 2024
Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed to age-related comorbidities, weakened immune function, and reduced tolerance to treatment-related adverse effects. In the immune checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting the discovery of predictive biomarkers for ICI treatment.
View Article and Find Full Text PDFPrevalence and clinical implications of biochemical hypogonadism in patients with nonobstructive azoospermia undergoing infertility evaluation.
F S Rep
March 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, São Paulo, Brazil.
Article Synopsis
- - The study aimed to assess how common biochemical hypogonadism is among infertile men with nonobstructive azoospermia (NOA) and its effects on clinical outcomes.
- - Out of 767 patients studied from 2014 to 2021, 80.8% were found to have biochemical hypogonadism, with various group distributions based on hormone levels: 42.4% hypergonadotropic hypogonadal, 38.5% normogonadotropic hypogonadal, and smaller percentages in the eugonadal groups.
- - Factors like reduced testicular volume, lower estradiol levels, and older paternal age were identified as increasing the risk of hypogonadism
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!