AI Article Synopsis
- CAG repeats are variable nucleotide sequences in the androgen receptor gene that may influence male infertility, but previous studies have shown mixed results on their association.
- An updated meta-analysis reviewed data from 40 studies, involving over 7,000 participants, and found that longer CAG repeat lengths were statistically linked to higher instances of male infertility.
- The study noted that this association was primarily significant in Caucasian populations, while no difference was seen for those with azoospermia and severe oligozoospermia.
Article Abstract
CAG repeats are polymorphic nucleotide repeats present in the androgen receptor gene. Many studies have estimated the association between CAG repeat length and male infertility, but the conclusions are controversial. Previous meta-analyses have come to different conclusions; however, new studies have been published. An updated meta-analysis was conducted. PubMed, CBM, CNKI and Web of Science databases were systematically searched for studies published from 1 January 2000 to 1 October 2015. Case-control studies on the association between CAG repeat length and male infertility using appropriate methodology were included. Forty studies were selected, including 3858 cases and 3161 controls. Results showed statistically significantly longer CAG repeat length among cases compared with controls (SMD = 0.14; 95% CI, 0.02-0.26). Shorter repeat length was associated with a lower risk of male infertility compared with a longer repeat length in the overall analysis (OR = 0.79, 95% CI: 0.66-0.95). Moreover, CAG repeat length was associated with male infertility in Caucasian populations, but not Asian or Egyptian populations. Subgroup analysis revealed no significant difference in German populations, but CAG repeat length was associated with male infertility in China and the USA. There were no significant differences between cases and controls in azoospermia and severe oligozoospermia.
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| http://dx.doi.org/10.1016/j.rbmo.2016.03.012 | DOI Listing |
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