AI Article Synopsis
- * They are especially important in kidney epithelial cells, helping to maintain water balance in the body.
- * The review discusses AQPs' roles in kidney tubules, their impact on water homeostasis and related disorders, as well as diagnostic and treatment strategies for these conditions.
Article Abstract
Aquaporins (AQPs) are a 13 member family (AQP0-12) of proteins that act as channels, through which water and, for some family members, glycerol, urea and other small solutes can be transported. Aquaporins are highly abundant in kidney epithelial cells where they play a critical role with respect to water balance. In this review we summarize the current knowledge with respect to the localization and function of AQPs within the kidney tubule, and their role in mammalian water homeostasis and the water balance disorders. Overviews of practical aspects with regard to differential diagnosis for some of these disorders, alongside treatment strategies are also discussed.
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| http://dx.doi.org/10.1016/j.beem.2016.02.012 | DOI Listing |
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