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Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China. | LitMetric

Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China.

Tuberculosis (Edinb)

Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Institute of Biomedical Sciences, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China. Electronic address:

Published: May 2016

AI Article Synopsis

Article Abstract

Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, however, there are relatively few available data on PZA resistant (PZA-R) rate in China. From June 2009 to June 2012, we selected 493 isolates from five field settings in China to investigate PZA-R by pncA gene sequencing. The result showed that PZA-R rate was 1.0% (2/196) among pan-susceptible isolates, 3.1% (4/130) among isoniazid (INH) mono-resistant isolates, 14.0% (6/43) among rifampin (RIF) mono-resistant isolates and 43.5% (54/124) among multidrug resistant (MDR) isolates. MDR tuberculosis (TB), RIF mono-resistance, and retreatment were found to be risk factors for PZA-R. Newly diagnosed PZA-R TB patients and clustered isolates with identical pncA mutations indicate that transmission of PZA-R isolates plays an important role in emergence of PZA-R TB. The results suggest that, it is necessary to conduct PZA susceptibility test among MDR isolates and modify the treatment regimens accordingly.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647815PMC
http://dx.doi.org/10.1016/j.tube.2016.02.008DOI Listing

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