This study aims to evaluate the effectiveness of a newly designed construction uniform in combating heat stress. Ten male volunteers performed treadmill running in a climatic chamber maintained at 34.5 °C temperature, 75% relative humidity, 0.3 m/s air velocity, and solar radiation of 450 W/m(2) that simulates typical summer working environment of construction sites in Hong Kong. The participants were tested while wearing two kinds of construction uniforms: a commonly worn uniform A, or a newly designed uniform B. It was found during exercise that Tc (38.34 ± 0.14 vs 38.45 ± 0.11 °C, p = 0.03), Tsk (36.01 ± 0.36 vs 36.27 ± 0.34 °C, p = 0.03), HR (162.7 ± 10.1 vs 172.5 ± 9.2 bpm, p < 0.01), PSI (7.0 ± 0.4 vs 7.5 ± 0.5, p = 0.04), thermal sensation (1.7 ± 0.9 vs 2.6 ± 0.7, p = 0.02), and wetness sensation (1.9 ± 0.9 vs 2.6 ± 0.8, p < 0.01) was lower when wearing uniform B than that of uniform A. It was found during recovery that Tc (37.89 ± 0.13 vs 38.06 ± 0.13 °C, p < 0.01), Tsk (35.68 ± 0.37 vs 36.02 ± 0.41 °C, p < 0.01), HR (104.2 ± 10.1 vs 112.6 ± 10.7 bpm, p < 0.01), PSI (3.3 ± 0.7 vs 4.1 ± 1.0, p < 0.01), thermal sensation (0.1 ± 0.9 vs 1.0 ± 0.8, p = 0.02), and wetness sensation (1.1 ± 1.0 vs 2.3 ± 0.8, p = 0.02) was lower when wearing uniform B than that of uniform A. The findings of this study suggested the newly designed construction uniform could reduce thermoregulatory and cardiovascular strain, and improve thermal comfort while exercising in a hot and humid environment.
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http://dx.doi.org/10.1016/j.apergo.2016.04.011 | DOI Listing |
Cancer Control
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, P.R. China.
Purpose: Splenic metastases (SM) from breast cancer (SMBC) are exceedingly rare. To date, the relevant literature is primarily based on pan-tumour species, with only a few studies exploring SM specifically in relation to breast cancer. As such, the present retrospective study explored the clinicopathological characteristics and prognoses of patients with SMBC at the breast care centre of the authors' hospital.
View Article and Find Full Text PDFBMC Complement Med Ther
January 2025
Geriatric department, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shi-er-qiao Road, Chengdu, 610072, Sichuan, China.
Background: Frailty is a common geriatric syndrome worldwide, and its early identification and intervention have important clinical significance. Resistance training has been recommended as an efficient means to combat loss of muscle strength and mass; however, it is often not a prioritized option for older adults. Tai chi is a well-known traditional Chinese exercise that has a beneficial impact on physical performance, balance ability, metabolism, and immune function.
View Article and Find Full Text PDFBMC Bioinformatics
January 2025
MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
Background: CRISPRi screening has become a powerful approach for functional genomic research. However, the off-target effects resulting from the mismatch tolerance between sgRNAs and their intended targets is a primary concern in CRISPRi applications.
Results: We introduce Guide Library Designer (GLiDe), a web-based tool specifically created for the genome-scale design of sgRNA libraries tailored for CRISPRi screening in prokaryotic organisms.
Sci Rep
January 2025
Environmental Geochemistry group, Department of Geosciences and Geography, University of Helsinki, Helsinki, Finland.
The two-stage channel (TSC) design with a vegetated man-made floodplain has been recommended as an alternative to conventional re-dredging for managing suspended sediment (SS) and nutrient loads in agricultural streams. However, there are currently uncertainties surrounding the efficiency of TSCs, since mass balances covering the whole annual hydrograph and including different periods of the channel life cycle are lacking. This paper aims to improve understanding of the medium-term morphological development and sedimentary nutrient retention when a dredged, trapezoidal-shaped channel is converted into a TSC, using a mass balance estimate of nutrient and carbon retention from immediately after excavation until the establishment of approximate biogeochemical equilibrium retention.
View Article and Find Full Text PDFSci Rep
January 2025
Chemistry Department, Faculty of Science, Damietta University, Damietta, New-Damietta, 34517, Egypt.
To shed light on the significance of thiazole derivatives in the advancement of cancer medication and to contribute to therapeutic innovation, we have designed the synthesis and antiproliferative activity investigation of 5-(1,3-dioxoisoindolin-2-yl)-7-(4-nitrophenyl)-2-thioxo-3,7-dihydro-2H-pyrano[2,3-d] thiazole-6-carbonitrile, the structure of thiazole derivative was confirmed by spectroscopic techniques UV, IR and NMR. The cytotoxic activity (in vitro) of the new hybrid synthesized compound on five human cancer cell lines; human liver hepatocellular carcinoma (HepG-2), colorectal carcinoma (HCT-116), breast adenocarcinoma (MCF-7), and epithelioid carcinoma (Hela), and a normal human lung fibroblast (WI-38) was studied using MTT assay. The compound exhibited a strong cytotoxicity effect against HepG-2 and MCF-7.
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