AI Article Synopsis
- FREGAT is an R package designed for region-based association analysis of quantitative traits, suitable for both family and population samples.
- It incorporates various methods, such as burden tests and kernel machine-based regression, making it versatile for genome/exome-wide studies and candidate gene analysis.
- The package is available online, along with supplementary data, and aims to enhance the effectiveness and applicability of association analyses.
Article Abstract
Unlabelled: Several approaches to the region-based association analysis of quantitative traits have recently been developed and successively applied. However, no software package has been developed that implements all of these approaches for either independent or structured samples. Here we introduce FREGAT (Family REGional Association Tests), an R package that can handle family and population samples and implements a wide range of region-based association methods including burden tests, functional linear models, and kernel machine-based regression. FREGAT can be used in genome/exome-wide region-based association studies of quantitative traits and candidate gene analysis. FREGAT offers many useful options to empower its users and increase the effectiveness and applicability of region-based association analysis.
Availability And Implementation: https://cran.r-project.org/web/packages/FREGAT/index.html
Supplementary Information: Supplementary data are available at Bioinformatics Online.
Contact: belon@bionet.nsc.ru.
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| http://dx.doi.org/10.1093/bioinformatics/btw160 | DOI Listing |
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