Signal-directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigenetic regulation. In this issue, Yi et al. (2016) reveal how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repress expression of anti-adipogenic developmental regulators.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500018 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2016.04.018 | DOI Listing |
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