AI Article Synopsis
- Amniotic membrane transplantation (AMT) is used to treat acute ocular chemical burns by promoting healing and reducing inflammation.
- A study analyzed outcomes of 72 eyes from 54 patients treated with AMT over a 10-year period, demonstrating that 40.3% achieved good visual acuity post-treatment.
- While AMT shows promise in enhancing recovery and restoring eye surface integrity, patients with severe burns and limbal stem cell deficiency may still face long-term vision challenges.
Article Abstract
Background: Amniotic membrane transplantation (AMT) has been used in the management of acute ocular chemical burns to promote epithelialisation, reduce inflammation and restore ocular surface integrity. The aim of this study is to analyse the morphological and functional outcomes of patients receiving AMT after ocular chemical burn.
Methods: We performed a retrospective analysis of all patients treated for acute ocular chemical burn between 1998 and 2008 in two participating centres (University of Duisburg-Essen, Germany and Royal Victoria Infirmary, Department of Ophthalmology, Newcastle University, UK). Ocular chemical burns were classified by Roper-Hall and Dua classifications.
Results: 72 eyes of 54 consecutive patients aged 37.3 years (±SD 11.6 years) were included in this cohort study. 7 chemical burns were acid burns, 61 were alkaline and 4 were of unknown origin. In 37 eyes (51.4%), AMT was applied within the first 6 days after injury. Mean follow-up time was 36.4 months (median 18.5; 1.3-117.3 months). Overall, 29 eyes (40.3%) achieved a best-corrected visual acuity of LogMAR 0.2 (0.63 decimal) or better at final visit. Complete 360° limbal stem cell deficiency (LSCD) occurred in 33 eyes (45.8%), while partial LSCD occurred in 21 eyes (29.2%).
Conclusion: AMT is an effective adjunctive treatment in the management of acute ocular chemical burns to support epithelial healing and restore ocular surface integrity with potential to improve vision. However, long-term debilitated vision remained in those with severe burns complicated by LSCD.
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| http://dx.doi.org/10.1136/bjophthalmol-2015-308037 | DOI Listing |
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