AI Article Synopsis

  • Sleep deprivation can cause mood disorders, cognitive dysfunction, and motor coordination issues, with no effective drug treatment currently available.
  • A study tested the effects of Tinospora cordifolia extract on sleep-deprived rats, indicating that those treated with the extract showed improved anxiety and cognitive scores compared to untreated sleep-deprived rats.
  • The TCE pretreatment also influenced brain protein markers related to stress, plasticity, inflammation, and apoptosis, suggesting it could be a potential way to manage the negative effects of sleep deprivation.

Article Abstract

Sleep deprivation (SD) leads to the spectrum of mood disorders like anxiety, cognitive dysfunctions and motor coordination impairment in many individuals. However, there is no effective pharmacological remedy to negate the effects of SD. The current study examined whether 50% ethanolic extract of Tinospora cordifolia (TCE) can attenuate these negative effects of SD. Three groups of adult Wistar female rats - (1) vehicle treated-sleep undisturbed (VUD), (2) vehicle treated-sleep deprived (VSD) and (3) TCE treated-sleep deprived (TSD) animals were tested behaviorally for cognitive functions, anxiety and motor coordination. TSD animals showed improved behavioral response in EPM and NOR tests for anxiety and cognitive functions, respectively as compared to VSD animals. TCE pretreatment modulated the stress induced-expression of plasticity markers PSA-NCAM, NCAM and GAP-43 along with proteins involved in the maintenance of LTP i.e., CamKII-α and calcineurin (CaN) in hippocampus and PC regions of the brain. Interestingly, contrary to VSD animals, TSD animals showed downregulated expression of inflammatory markers such as CD11b/c, MHC-1 and cytokines along with inhibition of apoptotic markers. This data suggests that TCE alone or in combination with other memory enhancing agents may help in managing sleep deprivation associated stress and improving cognitive functions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857086PMC
http://dx.doi.org/10.1038/srep25564DOI Listing

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