AI Article Synopsis
- MicroRNAs (miRNAs) are small non-coding RNAs around 22 nucleotides long that regulate various biological processes by targeting mRNAs for repression or degradation.
- The STarMirDB database compiles predictions of miRNA binding sites from studies and allows searches by miRNAs or mRNAs, providing detailed information about target interactions.
- Results from the database include various structural features and high-resolution diagrams of miRNA:target hybrids for easy visualization and use in research.
Article Abstract
microRNAs (miRNAs) are an abundant class of small endogenous non-coding RNAs (ncRNAs) of ∼22 nucleotides (nts) in length. These small regulatory molecules are involved in diverse developmental, physiological and pathological processes. miRNAs target mRNAs (mRNAs) for translational repression and/or mRNA degradation. Predictions of miRNA binding sites facilitate experimental validation of miRNA targets. Models developed with data from CLIP studies have been used for predictions of miRNA binding sites in the whole transcriptomes of human, mouse and worm. The prediction results have been assembled into STarMirDB, a new database of miRNA binding sites available at http://sfold.wadsworth.org/starmirDB.php . STarMirDB can be searched by miRNAs or mRNAs separately or in combination. The search results are categorized into seed and seedless sites in 3' UTR, CDS and 5' UTR. For each predicted site, STarMirDB provides a comprehensive list of sequence, thermodynamic and target structural features that are known to influence miRNA: target interaction. A high resolution PDF diagram of the conformation of the miRNA:target hybrid is also available for visualization and publication. The results of a database search are available through both an interactive viewer and downloadable text files.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962797 | PMC |
| http://dx.doi.org/10.1080/15476286.2016.1182279 | DOI Listing |
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