Objective: To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder (NMOSD).
Methods: This was a cross-sectional study including 36 aquaporin-4 antibody-positive (AQP4 Ab-positive) Caucasian patients with NMOSD and healthy controls matched for age, sex, and education. Volumetry of deep gray matter structures (DGM; thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens) was performed using 2 independent automated methods. Microstructural integrity was assessed based on diffusion tensor imaging.
Results: Both volumetric analysis methods consistently revealed similar volumes of DGM structures in patients and controls without significant group differences. Moreover, no differences in DGM microstructural integrity were observed between groups.
Conclusions: Deep gray matter structures are not affected in AQP4 Ab-positive Caucasian patients with NMOSD. NMOSD imaging studies should be interpreted with respect to Ab status, educational background, and ethnicity of included patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841641 | PMC |
| http://dx.doi.org/10.1212/NXI.0000000000000229 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Influence of lung function on macro- and micro-structural brain changes in mid- and late-life.
Int J Surg
January 2025
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Introduction: Lung function has been associated with cognitive decline and dementia, but the extent to which lung function impacts brain structural changes remains unclear. We aimed to investigate the association of lung function with structural macro- and micro-brain changes across mid- and late-life.
Methods: The study included a total of 37 164 neurologic disorder-free participants aged 40-70 years from the UK Biobank, who underwent brain MRI scans 9 years after baseline.
Quantum Molecular Dynamics Approach to Understanding Interactions in Betaine Chloride and Amino Acid Natural Deep Eutectic Solvents.
ACS Phys Chem Au
January 2025
Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, 12247-014 São Paulo, Brazil.
The unique properties and versatile applications of natural deep eutectic solvents (NaDES) have sparked significant interest in the field of green chemistry. Comprised of natural components that form liquids at room temperature through strong noncovalent electrostatic interaction, these solvents are cost-effective, nontoxic, and versatile. Betaine chloride-based NaDES, in particular, have shown promise in biocatalysis and sugar extraction due to their excellent properties.
View Article and Find Full Text PDFInfluence of Initial Gap, Voltage, and Additives on Zinc Microcolumn Morphology by Local Electrochemical Deposition.
Sensors (Basel)
January 2025
State Key Laboratory of High Performance Complex Manufacturing, Changsha 410083, China.
Local electrochemical deposition (LECD) is an innovative additive manufacturing technology capable of achieving precise deposition of metallic microstructures. This study delves into the ramifications of pivotal operational parameters-namely, the initial electrode gap, deposition voltage, and additive concentration-on the morphology of zinc microcolumns fabricated through LECD. A holistic approach integrating experimental methodologies with finite element simulations was adopted to scrutinize the influence of these variables on the microcolumns' dimensions, surface morphology, and structural integrity.
View Article and Find Full Text PDFInfluence of Spray Angle on Scratch Resistance of Cold-Sprayed SS316L Deposits.
Materials (Basel)
January 2025
Research and Testing Institute Pilsen, 30100 Plzen, Czech Republic.
In this study, we investigated the effect of spray angle on the microstructure, bonding quality, and scratch resistance of cold-sprayed SS316L coatings on SS304 substrates. The coatings were deposited at spray angles of 45°, 60°, 75°, and 90° using a high-pressure cold spray system. A comprehensive analysis of the relationship between the spray angle and coating properties was conducted, with a particular focus on fracture toughness and porosity.
View Article and Find Full Text PDFEffect of Polypropylene and Straw Fiber Materials on the Unconfined Compressive Strength of Tailings and Wasted Stone Mixed Backfill.
Materials (Basel)
January 2025
School of Resources and Safety Engineering, Central South University, Changsha 410083, China.
Ensuring the mechanical performance of backfill materials while reducing cementation costs is a key challenge in mine backfill research. To address this, fiber materials such as polypropylene (PP) fiber and rice straw (RS) fiber have been incorporated into cement-based mixtures for mine backfilling. This study investigates the effects of PP and RS fibers on the mechanical properties, flow characteristics, and microstructure of Tailings and Wasted Stone Mixed Backfill (TWSMB).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!